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AKT1
Basic information
- Official gene symbol
-
AKT serine/threonine kinase 1
- Conventional gene symbol
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AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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PI3K/Akt/mTOR
- Chromosomal location
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14q32.33 (chr14:105236678..105258980, complement)
- Protein length
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480
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr14:105246445 | A | C | 3 / 14 | p.L52R | c.155T>G | COSV62572203 | Tier1 | 3 / 100 |
| chr14:105246551 | C | T | 3 / 14 | p.E17K | c.49G>A | COSV62571334 | Tier1 | 39 / 100 |
| chr14:105243048 | G | T | 4 / 14 | p.Q79K | c.235C>A | COSV62571663 | Tier1 | 2 / 100 |
| chr14:105243053 | C | A | 4 / 14 | p.C77F | c.230G>T | COSV62574159 | Tier2 | 1 / 100 |