Side Menu
ALK
Basic information
- Official gene symbol
-
ALK receptor tyrosine kinase
- Conventional gene symbol
-
CD246, NBLST3
- Classification
-
Oncogene
- Official gene ID
- Transcript ID
- Functional classification
-
Tumor growth and progression
- Signaling pathway
-
RTK
- Chromosomal location
-
2p23.2-p23.1 (chr2:29416090..30143525, complement)
- Protein length
-
1,620
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr2:29446296 | C | T | 20 / 29 | p.D1091N | c.3271G>A | COSV66566475 | Tier1 | 1 / 182 |
| chr2:29445418 | G | A | 21 / 29 | p.P1139S | c.3415C>T | Tier1 | 1 / 182 |