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ARID1B

Basic information

Official gene symbol
AT-rich interaction domain 1B
Conventional gene symbol
6A3-5, BAF250B, BRIGHT, CSS1, DAN15, ELD/OSA1, MRD12, OSA2, P250R
Classification
Tumor suppressor gene
Official gene ID
57492(Refseq)
57492 (KEGG)
Transcript ID
NM_017519
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
6q25.3 (chr6:157099064..157529025)
Protein length
2,236

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr6:157150436 C T 2 / 19 p.Q540* c.1618C>T COSV99266603 Tier2 1 / 142
chr6:157405991 G T 5 / 19 p.G732* c.2194G>T COSV51657331 Tier2 1 / 142
chr6:157488250 A ATGTT 9 / 19 p.S973fs c.2917_2918insTGTT   Tier2 1 / 142
chr6:157502271 C T 11 / 19 p.R1089* c.3265C>T COSV51682477 Tier2 1 / 142
chr6:157505488 G T 12 / 19 p.E1144* c.3430G>T   Tier2 1 / 142
chr6:157517445 C T 15 / 19 p.R1324* c.3970C>T COSV51676754 Tier2 2 / 142
chr6:157520015 C T 16 / 19 p.Q1349* c.4045C>T COSV51652991 Tier2 1 / 142
chr6:157522598 C T 17 / 19 p.R1611* c.4831C>T COSV51670259 Tier2 3 / 142
chr6:157527550 G T 19 / 19 p.E1746* c.5236G>T COSV104368364 Tier2 1 / 142
chr6:157527837 TAGAA T 19 / 19 p.K1844fs c.5531_5534delAAGA   Tier2 1 / 142
chr6:157527847 G T 19 / 19 p.E1845* c.5533G>T   Tier2 1 / 142
chr6:157528051 C T 19 / 19 p.R1913* c.5737C>T COSV51675024 Tier2 1 / 142
chr6:157528122 CAATA C 19 / 19 p.N1937fs c.5809_5812delAATA   Tier2 1 / 142
chr6:157528243 C T 19 / 19 p.R1977* c.5929C>T COSV51666367 Tier2 2 / 142
chr6:157528658 G GAGAA 19 / 19 p.M2117fs c.6346_6349dupGAAA   Tier2 1 / 142