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ATR

Basic information

Official gene symbol
ATR serine/threonine kinase
Conventional gene symbol
FCTCS, FRP1, MEC1, SCKL, SCKL1
Classification
Tumor suppressor gene
Official gene ID
545(Refseq)
545 (KEGG)
Transcript ID
NM_001184
Functional classification
Genome maintenance
Signaling pathway
TP53
Chromosomal location
3q23 (chr3:142168271..142297546, complement)
Protein length
2,644

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr3:142284984 C A 3 / 47 p.E91* c.271G>T COSV63383734 Tier2 1 / 125
chr3:142281802 C A 4 / 47 p.E148* c.442G>T COSV63385454 Tier2 1 / 125
chr3:142280188 G A 5 / 47 p.Q416* c.1246C>T   Tier2 1 / 125
chr3:142278223 C T 7 / 47 p.W534* c.1602G>A   Tier2 1 / 125
chr3:142275264 TGCAATAAGATAAAAAATCCA T 9 / 47 p.S673fs c.2019_2038delTGGATTTTTTATCTTATTGC   Tier2 2 / 125
chr3:142269045 C A 14 / 47 p.E969* c.2905G>T COSV63386308 Tier2 1 / 125
chr3:142266741 TTC T 16 / 47 p.E1061fs c.3181_3182delGA   Tier2 1 / 125
chr3:142226775 G A 28 / 47 p.Q1677* c.5029C>T   Tier2 1 / 125
chr3:142226829 C A 28 / 47 p.E1659* c.4975G>T COSV63388634 Tier2 1 / 125
chr3:142224067 C A 29 / 47 p.E1704* c.5110G>T   Tier2 1 / 125
chr3:142212062 A C 35 / 47 p.L1997* c.5990T>G   Tier2 1 / 125
chr3:142188982 G A 37 / 47 p.R2089* c.6265C>T   Tier2 1 / 125
chr3:142168414 G A 47 / 47 p.R2598* c.7792C>T COSV53817531 Tier2 1 / 125