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ATRX

Basic information

Official gene symbol
ATRX chromatin remodeler
Conventional gene symbol
JMS, MRX52, RAD54, XH2, XNP, ZNF-HX
Classification
Tumor suppressor gene
Official gene ID
546(Refseq)
546 (KEGG)
Transcript ID
NM_000489
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
Xq21.1 (chrX:76763829..77041487, complement)
Protein length
2,492

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chrX:76972632 G A 2 / 35 p.R37* c.109C>T   Tier2 1 / 150
chrX:76937162 TC T 9 / 35 p.K1196fs c.3585delG   Tier2 1 / 150
chrX:76937318 T A 9 / 35 p.R1144* c.3430A>T   Tier2 1 / 150
chrX:76937425 G T 9 / 35 p.S1108* c.3323C>A   Tier2 1 / 150
chrX:76938029 G A 9 / 35 p.R907* c.2719C>T COSV64870748 Tier2 2 / 150
chrX:76938074 C A 9 / 35 p.E892* c.2674G>T   Tier2 1 / 150
chrX:76938281 T A 9 / 35 p.K823* c.2467A>T COSV64883624 Tier2 1 / 150
chrX:76938995 C A 9 / 35 p.E585* c.1753G>T COSV64883151 Tier2 1 / 150
chrX:76939950 G C 9 / 35 p.Y266* c.798C>G   Tier2 1 / 150
chrX:76931772 G C 10 / 35 p.S1253* c.3758C>G COSV100970239 Tier2 1 / 150
chrX:76918934 C A 12 / 35 p.G1353* c.4057G>T   Tier2 1 / 150
chrX:76918951 ACAGT A 12 / 35 p.T1346fs c.4036_4039delACTG COSV64872296 Tier2 1 / 150
chrX:76918997 T TA 12 / 35 p.K1332fs c.3993dupT COSV64872576 Tier2 1 / 150
chrX:76912095 CT C 13 / 35 p.S1390fs c.4168delA   Tier2 2 / 150
chrX:76909659 G A 14 / 35 p.Q1416* c.4246C>T COSV100971607 Tier2 1 / 150
chrX:76874423 C A 21 / 35 p.E1767* c.5299G>T   Tier2 1 / 150
chrX:76855017 TC T 25 / 35 p.D1940fs c.5818delG   Tier2 1 / 150
chrX:76814253 G A 29 / 35 p.R2131* c.6391C>T COSV64881210 Tier2 1 / 150