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AXIN1

Basic information

Official gene symbol
axin 1
Conventional gene symbol
AXIN, PPP1R49
Classification
Tumor suppressor gene
Official gene ID
8312(Refseq)
8312 (KEGG)
Transcript ID
NM_003502
Functional classification
Differentiation
Signaling pathway
WNT
Chromosomal location
16p13.3 (chr16:338122..397025, complement)
Protein length
862

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr16:396701 C A 2 / 11 p.E109* c.325G>T   Tier2 1 / 90
chr16:396772 C T 2 / 11 p.W85* c.254G>A COSV51982971 Tier2 1 / 90
chr16:347780 G A 6 / 11 p.R576* c.1726C>T COSV51991391 Tier2 1 / 90
chr16:347831 G A 6 / 11 p.Q559* c.1675C>T   Tier2 1 / 90
chr16:347909 G A 6 / 11 p.R533* c.1597C>T COSV51982725 Tier2 1 / 90
chr16:348251 C A 6 / 11 p.E419* c.1255G>T COSV51992704 Tier2 1 / 90
chr16:343507 G A 8 / 11 p.R723* c.2167C>T COSV51995320 Tier2 1 / 90
chr16:338190 G A 11 / 11 p.R841* c.2521C>T COSV51993019 Tier2 1 / 90
chr16:338238 T TG 11 / 11 p.K825fs c.2472dupC   Tier2 1 / 90