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BRAF

Basic information

Official gene symbol
B-Raf proto-oncogene, serine/threonine kinase
Conventional gene symbol
B-RAF1, B-raf, BRAF1, NS7, RAFB1
Classification
Oncogene
Official gene ID
673(Refseq)
673 (KEGG)
Transcript ID
NM_004333
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
7q34 (chr7:140434397..140624503, complement)
Protein length
766

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr7:140501331 A C 6 / 18 p.F247L c.741T>G COSV56165267 Tier2 1 / 200
chr7:140481393 T C 11 / 18 p.Y472C c.1415A>G COSV56067953 Tier1 1 / 200
chr7:140481397 C A 11 / 18 p.V471F c.1411G>T COSV56229839 Tier1 1 / 200
chr7:140481402 C G 11 / 18 p.G469A c.1406G>C COSV56061424 Tier1 4 / 200
chr7:140481402 C T 11 / 18 p.G469E c.1406G>A COSV56065622 Tier1 2 / 200
chr7:140481403 C T 11 / 18 p.G469R c.1405G>A COSV56070557 Tier1 1 / 200
chr7:140481403 C G 11 / 18 p.G469R c.1405G>C COSV56082352 Tier1 1 / 200
chr7:140481408 G A 11 / 18 p.S467L c.1400C>T COSV56106484 Tier1 1 / 200
chr7:140481411 C T 11 / 18 p.G466E c.1397G>A COSV56059390 Tier1 1 / 200
chr7:140481411 C G 11 / 18 p.G466A c.1397G>C COSV56070593 Tier1 1 / 200
chr7:140481411 C A 11 / 18 p.G466V c.1397G>T COSV56057462 Tier1 2 / 200
chr7:140481412 C G 11 / 18 p.G466R c.1396G>C COSV56064038 Tier2 1 / 200
chr7:140481412 C T 11 / 18 p.G466R c.1396G>A COSV56099462 Tier2 1 / 200
chr7:140481478 G A 11 / 18 p.R444W c.1330C>T COSV56083156 Tier2 1 / 200
chr7:140477836 GTAGGTGCTGTCACAT G 12 / 18 p.N486_P490del c.1457_1471delATGTGACAGCACCTA COSV56100024 Tier2 1 / 200
chr7:140477853 C G 12 / 18 p.L485F c.1455G>C   Tier2 1 / 200
chr7:140477861 T C 12 / 18 p.K483E c.1447A>G COSV56236813 Tier2 1 / 200
chr7:140453132 T A 15 / 18 p.K601N c.1803A>T COSV56058093 Tier1 1 / 200
chr7:140453134 T C 15 / 18 p.K601E c.1801A>G COSV56058494 Tier1 6 / 200
chr7:140453136 A T 15 / 18 p.V600E c.1799T>A COSV56056643 Tier1 100 / 200
chr7:140453145 A T 15 / 18 p.L597Q c.1790T>A COSV56072463 Tier1 1 / 200
chr7:140453148 C A 15 / 18 p.G596V c.1787G>T COSV99951808 Tier2 2 / 200
chr7:140453154 T C 15 / 18 p.D594G c.1781A>G COSV56065695 Tier1 10 / 200
chr7:140453154 T G 15 / 18 p.D594A c.1781A>C COSV56224199 Tier1 1 / 200
chr7:140453155 C T 15 / 18 p.D594N c.1780G>A COSV56061673 Tier1 5 / 200
chr7:140453193 T A 15 / 18 p.N581I c.1742A>T COSV56106422 Tier1 2 / 200
chr7:140453193 T C 15 / 18 p.N581S c.1742A>G COSV56058108 Tier1 2 / 200