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CASP8

Basic information

Official gene symbol
caspase 8
Conventional gene symbol
ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Classification
Tumor suppressor gene
Official gene ID
841(Refseq)
841 (KEGG)
Transcript ID
NM_033355
Functional classification
Cell death
Signaling pathway
Apoptosis
Chromosomal location
2q33.1 (chr2:202131210..202151317)
Protein length
479

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr2:202131303 C T 3 / 10 p.Q32* c.94C>T COSV51861286 Tier2 1 / 118
chr2:202131383 TC T 3 / 10 p.L59fs c.175delC   Tier2 1 / 118
chr2:202131411 C T 3 / 10 p.R68* c.202C>T COSV51846869 Tier2 5 / 118
chr2:202136284 GAGGTCTTTTAAGTTTCTTTTGCAAGAGGA G 4 / 10 p.R118fs c.353_381delGGTCTTTTAAGTTTCTTTTGCAAGAGGAA   Tier2 1 / 118
chr2:202136317 C CTCCAAATGCAAACTGGA 4 / 10 p.D135fs c.386_402dupCCAAATGCAAACTGGAT   Tier2 1 / 118
chr2:202137394 AG A 5 / 10 p.V150fs c.448delG   Tier2 1 / 118
chr2:202137438 CTG C 5 / 10 p.A165fs c.492_493delTG COSV51859272 Tier2 1 / 118
chr2:202137445 C T 5 / 10 p.Q166* c.496C>T   Tier2 1 / 118
chr2:202137487 G T 5 / 10 p.E180* c.538G>T COSV51861924 Tier2 1 / 118
chr2:202137640 AG A 6 / 10 p.G191fs c.572delG   Tier2 1 / 118
chr2:202139671 T TCA 7 / 10 p.Q220fs c.658_659dupCA   Tier2 1 / 118
chr2:202149751 C T 9 / 10 p.Q339* c.1015C>T COSV51852083 Tier2 1 / 118
chr2:202149773 CT C 9 / 10 p.S347fs c.1039delT   Tier2 1 / 118
chr2:202149860 C G 9 / 10 p.S375* c.1124C>G COSV51851118 Tier2 1 / 118
chr2:202149913 AT A 9 / 10 p.I393fs c.1178delT   Tier2 1 / 118
chr2:202149960 CTG C 9 / 10 p.V410fs c.1228_1229delGT COSV51845190 Tier1 1 / 118
chr2:202150030 C T 9 / 10 p.R432* c.1294C>T COSV51845077 Tier2 3 / 118
chr2:202150039 C T 9 / 10 p.R435* c.1303C>T COSV51844657 Tier2 4 / 118
chr2:202151270 C T 10 / 10 p.Q465* c.1393C>T COSV51844901 Tier2 2 / 118