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CDH1

Basic information

Official gene symbol
cadherin 1
Conventional gene symbol
Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO
Classification
Tumor suppressor gene
Official gene ID
999(Refseq)
999 (KEGG)
Transcript ID
NM_004360
Functional classification
Differentiation
Signaling pathway
WNT
Chromosomal location
16q22.1 (chr16:68771319..68867402)
Protein length
882

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr16:68771330 G A 1 / 16 p.W4* c.12G>A COSV55729433 Tier2 1 / 123
chr16:68772218 C T 2 / 16 p.Q23* c.67C>T COSV55726950 Tier2 2 / 123
chr16:68835629 C T 3 / 16 p.R74* c.220C>T COSV55732282 Tier2 2 / 123
chr16:68842731 G T 5 / 16 p.E223* c.667G>T   Tier2 1 / 123
chr16:68844172 G A 6 / 16 p.D254N c.760G>A COSV55729198 Tier1 1 / 123
chr16:68845682 G T 7 / 16 p.E310* c.928G>T COSV55736918 Tier2 1 / 123
chr16:68846049 G GTATA 8 / 16 p.T342fs c.1021_1024dupTATA   Tier2 1 / 123
chr16:68847324 TTGAA T 9 / 16 p.N417fs c.1250_1253delATGA   Tier2 1 / 123
chr16:68849487 GTC G 10 / 16 p.L466fs c.1397_1398delTC COSV55742602 Tier2 1 / 123
chr16:68849586 G T 10 / 16 p.E497* c.1489G>T COSV55735504 Tier2 1 / 123
chr16:68853277 G GAGCACGTGAAGAAC 11 / 16 p.Y561fs c.1668_1681dupGAAGAACAGCACGT   Tier2 1 / 123
chr16:68856093 C T 12 / 16 p.A634V c.1901C>T COSV55730231 Tier1 1 / 123
chr16:68856106 G A 12 / 16 p.W638* c.1914G>A COSV55734935 Tier2 1 / 123
chr16:68857307 G T 13 / 16 p.E648* c.1942G>T COSV55735390 Tier2 2 / 123
chr16:68857460 C T 13 / 16 p.Q699* c.2095C>T COSV55727343 Tier2 1 / 123
chr16:68862107 G A 14 / 16 p.R732Q c.2195G>A COSV55728376 Tier2 1 / 123
chr16:68867259 G T 16 / 16 p.E836* c.2506G>T   Tier2 1 / 123
chr16:68867310 TCAGA T 16 / 16 p.D854fs c.2560_2563delGACA   Tier2 1 / 123