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CDK12

Basic information

Official gene symbol
cyclin dependent kinase 12
Conventional gene symbol
CRK7, CRKR, CRKRS
Classification
Tumor suppressor gene
Official gene ID
51755(Refseq)
51755 (KEGG)
Transcript ID
NM_016507
Functional classification
Transcriptional regulation
Signaling pathway
Transcriptional regulation
Chromosomal location
17q12 (chr17:37618325..37687569)
Protein length
1,490

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr17:37618955 A T 1 / 14 p.K211* c.631A>T   Tier2 1 / 92
chr17:37619054 CAAGAT C 1 / 14 p.Q244fs c.731_735delAAGAT   Tier2 1 / 92
chr17:37619288 C T 1 / 14 p.R322* c.964C>T   Tier2 1 / 92
chr17:37627215 C A 2 / 14 p.S377* c.1130C>A   Tier2 1 / 92
chr17:37680973 C T 12 / 14 p.R1048* c.3142C>T COSV71002836 Tier2 2 / 92
chr17:37681030 C T 12 / 14 p.R1067* c.3199C>T COSV70999846 Tier2 1 / 92
chr17:37681071 G GT 12 / 14 p.N1081fs c.3240_3241insT   Tier2 1 / 92
chr17:37682554 C T 13 / 14 p.Q1249* c.3745C>T   Tier2 1 / 92
chr17:37687162 C T 14 / 14 p.R1356* c.4066C>T COSV101420297 Tier2 1 / 92