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CDKN1B

Basic information

Official gene symbol
cyclin dependent kinase inhibitor 1B
Conventional gene symbol
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Classification
Tumor suppressor gene
Official gene ID
1027(Refseq)
1027 (KEGG)
Transcript ID
NM_004064
Functional classification
Cell cycle
Signaling pathway
Cell cycle
Chromosomal location
12p13.1 (chr12:12870774..12871880)
Protein length
198

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr12:12870853 C A 1 / 3 p.S27* c.80C>A COSV57431591 Tier2 1 / 32
chr12:12870861 AG A 1 / 3 p.N31fs c.90delG   Tier2 1 / 32
chr12:12870876 CCG C 1 / 3 p.P35fs c.104_105delCG   Tier2 1 / 32
chr12:12870883 A ACCTT 1 / 3 p.H38fs c.112_113insTTCC   Tier2 1 / 32
chr12:12870930 G T 1 / 3 p.E53* c.157G>T   Tier2 1 / 32
chr12:12870952 G A 1 / 3 p.W60* c.179G>A COSV57429721 Tier2 1 / 32
chr12:12870971 TCA T 1 / 3 p.H67fs c.201_202delCA COSV99964038 Tier2 1 / 32
chr12:12871037 C A 1 / 3 p.Y88* c.264C>A   Tier2 1 / 32
chr12:12871101 A AT 1 / 3 p.S110fs c.328_329insT   Tier2 1 / 32
chr12:12871144 ACT A 1 / 3 p.S125fs c.374_375delCT COSV57431970 Tier2 1 / 32
chr12:12871149 G T 1 / 3 p.E126* c.376G>T   Tier2 1 / 32
chr12:12871221 G T 1 / 3 p.G150* c.448G>T   Tier2 1 / 32
chr12:12871797 G T 2 / 3 p.E172* c.514G>T COSV57430128 Tier2 1 / 32