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CHEK2

Basic information

Official gene symbol
checkpoint kinase 2
Conventional gene symbol
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
Classification
Oncogene / Tumor suppressor gene
Official gene ID
11200(Refseq)
11200 (KEGG)
Transcript ID
NM_007194
Functional classification
Genome maintenance
Signaling pathway
TP53
Chromosomal location
22q12.1 (chr22:29083885..29130709, complement)
Protein length
543

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr22:29121018 C T 4 / 15 p.R180H c.539G>A COSV60417374 Tier1 2 / 45
chr22:29085164 CAGACAGAAGATCTT C 14 / 15 p.Q496fs c.1487_1500delAAGATCTTCTGTCT   Tier2 1 / 45
chr22:29083898 GCA G 15 / 15 p.A540fs c.1617_1618delTG COSV60427084 Tier2 1 / 45