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CIC

Basic information

Official gene symbol
capicua transcriptional repressor
Conventional gene symbol
MRD45
Classification
Oncogene / Tumor suppressor gene
Official gene ID
23152(Refseq)
23152 (KEGG)
Transcript ID
NM_015125
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
19q13.2 (chr19:42788857..42799343)
Protein length
1,608

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr19:42791030 C T 2 / 20 p.Q59* c.175C>T   Tier2 1 / 116
chr19:42791715 C T 5 / 20 p.R201W c.601C>T COSV50547633 Tier2 2 / 116
chr19:42791757 C T 5 / 20 p.R215W c.643C>T COSV50547203 Tier2 1 / 116
chr19:42791847 G T 5 / 20 p.E245* c.733G>T   Tier2 1 / 116
chr19:42792016 C T 6 / 20 p.R274* c.820C>T COSV50631758 Tier2 1 / 116
chr19:42793058 CCGTTGCA C 7 / 20 p.V318fs c.951_957delCGTTGCA   Tier2 1 / 116
chr19:42793214 ACAGT A 7 / 20 p.S370fs c.1110_1113delTCAG   Tier2 1 / 116
chr19:42793240 C T 7 / 20 p.Q378* c.1132C>T   Tier2 1 / 116
chr19:42793462 C T 8 / 20 p.R422* c.1264C>T COSV104381975 Tier2 1 / 116
chr19:42794881 C G 10 / 20 p.S654* c.1961C>G   Tier2 1 / 116
chr19:42796320 CCT C 12 / 20 p.Q992fs c.2973_2974delTC   Tier2 1 / 116
chr19:42796816 A AT 14 / 20 p.T1093fs c.3275dupT   Tier2 1 / 116
chr19:42797278 C T 15 / 20 p.R1214* c.3640C>T COSV50569160 Tier2 1 / 116
chr19:42797918 GC G 16 / 20 p.A1324fs c.3971delC   Tier2 1 / 116
chr19:42798216 C A 17 / 20 p.Y1390* c.4170C>A   Tier2 1 / 116
chr19:42798833 C T 19 / 20 p.Q1469* c.4405C>T   Tier2 1 / 116