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CREBBP

Basic information

Official gene symbol
CREB binding protein
Conventional gene symbol
CBP, KAT3A, MKHK1, RSTS, RSTS1
Classification
Oncogene / Tumor suppressor gene
Official gene ID
1387(Refseq)
1387 (KEGG)
Transcript ID
NM_004380
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
16p13.3 (chr16:3777719..3929917, complement)
Protein length
2,442

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr16:3900951 C A 2 / 31 p.G49* c.145G>T   Tier2 1 / 189
chr16:3832811 G A 6 / 31 p.R483* c.1447C>T COSV52120614 Tier2 1 / 189
chr16:3831263 GATCTGTTGTT G 7 / 31 p.T537fs c.1608_1617delAACAACAGAT   Tier2 1 / 189
chr16:3830780 C T 8 / 31 p.W592* c.1776G>A COSV52116906 Tier2 1 / 189
chr16:3828180 C A 10 / 31 p.E649* c.1945G>T   Tier2 1 / 189
chr16:3824685 G T 12 / 31 p.S723* c.2168C>A COSV99268203 Tier2 1 / 189
chr16:3820666 G A 14 / 31 p.Q929* c.2785C>T   Tier2 1 / 189
chr16:3820901 CTG C 14 / 31 p.Q850fs c.2548_2549delCA   Tier2 1 / 189
chr16:3808917 G A 17 / 31 p.R1103* c.3307C>T COSV52133173 Tier2 1 / 189
chr16:3808031 T A 18 / 31 p.K1130* c.3388A>T   Tier2 1 / 189
chr16:3807327 GGTACACAGCTGCTTCCCATA G 19 / 31 p.Y1214fs c.3640_3659delTATGGGAAGCAGCTGTGTAC   Tier2 1 / 189
chr16:3790455 G A 24 / 31 p.R1360* c.4078C>T COSV52117620 Tier2 1 / 189
chr16:3788617 C T 26 / 31 p.R1446H c.4337G>A COSV52112787 Tier2 1 / 189
chr16:3788617 C A 26 / 31 p.R1446L c.4337G>T COSV52125401 Tier2 1 / 189
chr16:3788618 G A 26 / 31 p.R1446C c.4336C>T COSV52113365 Tier2 3 / 189
chr16:3786652 TTGTAGTCATGGATGATCCGCTCTGCAAAC T 27 / 31 p.F1511fs c.4530_4558delGTTTGCAGAGCGGATCATCCATGACTACA   Tier2 1 / 189
chr16:3786719 G A 27 / 31 p.R1498* c.4492C>T COSV52113607 Tier2 1 / 189
chr16:3781267 G A 30 / 31 p.Q1700* c.5098C>T   Tier2 1 / 189
chr16:3781323 AAGG A 30 / 31 p.S1680del c.5039_5041delCCT COSV52112964 Tier2 4 / 189
chr16:3777760 T TC 31 / 31 p.T2430fs c.7287_7288insG   Tier2 1 / 189
chr16:3778141 G A 31 / 31 p.Q2303* c.6907C>T   Tier2 1 / 189
chr16:3778336 C A 31 / 31 p.G2238* c.6712G>T   Tier2 1 / 189
chr16:3778448 CTGCT C 31 / 31 p.Q2199fs c.6596_6599delAGCA   Tier2 1 / 189
chr16:3779239 T A 31 / 31 p.K1937* c.5809A>T   Tier2 1 / 189