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CTCF

Basic information

Official gene symbol
CCCTC-binding factor
Conventional gene symbol
CFAP108, FAP108, MRD21
Classification
Tumor suppressor gene
Official gene ID
10664(Refseq)
10664 (KEGG)
Transcript ID
NM_006565
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
16q22.1 (chr16:67644736..67671775)
Protein length
727

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr16:67644970 G T 3 / 12 p.E79* c.235G>T   Tier2 1 / 99
chr16:67645069 G T 3 / 12 p.E112* c.334G>T COSV50468639 Tier2 2 / 99
chr16:67645420 G T 3 / 12 p.E229* c.685G>T   Tier2 1 / 99
chr16:67645897 T A 4 / 12 p.C275* c.825T>A   Tier2 1 / 99
chr16:67645908 C G 4 / 12 p.S279* c.836C>G COSV99064249 Tier2 1 / 99
chr16:67645922 C T 4 / 12 p.H284Y c.850C>T COSV50461559 Tier2 1 / 99
chr16:67646012 A AAC 4 / 12 p.G318fs c.950_951dupCA COSV50461766 Tier2 1 / 99
chr16:67650710 C T 5 / 12 p.R339W c.1015C>T COSV50486171 Tier2 3 / 99
chr16:67650732 C CA 5 / 12 p.H347fs c.1037_1038insA   Tier2 1 / 99
chr16:67654610 T G 6 / 12 p.L366* c.1097T>G COSV50464447 Tier2 1 / 99
chr16:67654643 G A 6 / 12 p.R377H c.1130G>A COSV50461455 Tier2 2 / 99
chr16:67660469 C T 8 / 12 p.R457* c.1369C>T COSV50461417 Tier2 1 / 99
chr16:67662321 T TA 9 / 12 p.Y523fs c.1568dupA   Tier2 1 / 99
chr16:67663361 G T 10 / 12 p.G588* c.1762G>T   Tier2 1 / 99
chr16:67670620 AT A 11 / 12 p.N622fs c.1866delT   Tier2 1 / 99
chr16:67670715 C T 11 / 12 p.R654* c.1960C>T COSV50498832 Tier2 1 / 99