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CTNNB1
Basic information
- Official gene symbol
-
catenin beta 1
- Conventional gene symbol
-
CTNNB, EVR7, MRD19, NEDSDV, armadillo
- Classification
-
Oncogene
- Official gene ID
- Transcript ID
- Functional classification
-
Differentiation
- Signaling pathway
-
WNT
- Chromosomal location
-
3p22.1 (chr3:41265560..41280833)
- Protein length
-
781
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr3:41266097 | G | A | 3 / 15 | p.D32N | c.94G>A | COSV62687956 | Tier2 | 2 / 249 |
| chr3:41266097 | G | C | 3 / 15 | p.D32H | c.94G>C | COSV62688665 | Tier2 | 2 / 249 |
| chr3:41266097 | G | T | 3 / 15 | p.D32Y | c.94G>T | COSV62688134 | Tier1 | 9 / 249 |
| chr3:41266098 | A | G | 3 / 15 | p.D32G | c.95A>G | COSV62688001 | Tier2 | 5 / 249 |
| chr3:41266098 | A | C | 3 / 15 | p.D32A | c.95A>C | COSV62688037 | Tier2 | 2 / 249 |
| chr3:41266098 | A | T | 3 / 15 | p.D32V | c.95A>T | COSV62688249 | Tier2 | 2 / 249 |
| chr3:41266100 | T | G | 3 / 15 | p.S33A | c.97T>G | COSV62689225 | Tier1 | 2 / 249 |
| chr3:41266100 | T | C | 3 / 15 | p.S33P | c.97T>C | COSV62688086 | Tier2 | 2 / 249 |
| chr3:41266101 | C | G | 3 / 15 | p.S33C | c.98C>G | COSV62687839 | Tier1 | 9 / 249 |
| chr3:41266101 | C | T | 3 / 15 | p.S33F | c.98C>T | COSV62688300 | Tier1 | 9 / 249 |
| chr3:41266101 | C | A | 3 / 15 | p.S33Y | c.98C>A | COSV62688644 | Tier1 | 1 / 249 |
| chr3:41266103 | G | A | 3 / 15 | p.G34R | c.100G>A | COSV62687911 | Tier2 | 6 / 249 |
| chr3:41266103 | G | C | 3 / 15 | p.G34R | c.100G>C | COSV62687931 | Tier2 | 2 / 249 |
| chr3:41266104 | G | T | 3 / 15 | p.G34V | c.101G>T | COSV62687976 | Tier1 | 5 / 249 |
| chr3:41266104 | G | A | 3 / 15 | p.G34E | c.101G>A | COSV62688267 | Tier2 | 5 / 249 |
| chr3:41266107 | T | G | 3 / 15 | p.I35S | c.104T>G | COSV62687967 | Tier2 | 3 / 249 |
| chr3:41266110 | A | C | 3 / 15 | p.H36P | c.107A>C | COSV62688989 | Tier2 | 1 / 249 |
| chr3:41266112 | T | C | 3 / 15 | p.S37P | c.109T>C | COSV62688537 | Tier2 | 4 / 249 |
| chr3:41266112 | T | G | 3 / 15 | p.S37A | c.109T>G | COSV62688488 | Tier2 | 1 / 249 |
| chr3:41266113 | C | T | 3 / 15 | p.S37F | c.110C>T | COSV62687856 | Tier1 | 11 / 249 |
| chr3:41266113 | C | A | 3 / 15 | p.S37Y | c.110C>A | COSV62689256 | Tier1 | 4 / 249 |
| chr3:41266113 | C | G | 3 / 15 | p.S37C | c.110C>G | COSV62688281 | Tier1 | 5 / 249 |
| chr3:41266124 | A | G | 3 / 15 | p.T41A | c.121A>G | COSV62687862 | Tier1 | 22 / 249 |
| chr3:41266125 | C | T | 3 / 15 | p.T41I | c.122C>T | COSV62688008 | Tier2 | 3 / 249 |
| chr3:41266136 | T | C | 3 / 15 | p.S45P | c.133T>C | COSV62687880 | Tier1 | 8 / 249 |
| chr3:41266137 | C | T | 3 / 15 | p.S45F | c.134C>T | COSV62687872 | Tier1 | 10 / 249 |
| chr3:41266137 | C | A | 3 / 15 | p.S45Y | c.134C>A | COSV62689938 | Tier1 | 1 / 249 |
| chr3:41268766 | A | T | 7 / 15 | p.K335I | c.1004A>T | COSV62688046 | Tier2 | 3 / 249 |
| chr3:41274897 | T | C | 8 / 15 | p.W383R | c.1147T>C | COSV62701352 | Tier2 | 2 / 249 |
| chr3:41274897 | T | A | 8 / 15 | p.W383R | c.1147T>A | COSV62690170 | Tier2 | 1 / 249 |
| chr3:41274911 | T | A | 8 / 15 | p.N387K | c.1161T>A | COSV62688055 | Tier2 | 2 / 249 |
| chr3:41274911 | T | G | 8 / 15 | p.N387K | c.1161T>G | COSV62689041 | Tier2 | 2 / 249 |