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DICER1

Basic information

Official gene symbol
dicer 1, ribonuclease III
Conventional gene symbol
DCR1, Dicer, Dicer1e, GLOW, HERNA, K12H4.8-LIKE, MNG1, RMSE2
Classification
Tumor suppressor gene
Official gene ID
23405(Refseq)
23405 (KEGG)
Transcript ID
NM_030621
Functional classification
Transcriptional regulation
Signaling pathway
RNA metabolism
Chromosomal location
14q32.13 (chr14:95556835..95599795, complement)
Protein length
1,922

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr14:95596406 C A 7 / 29 p.E188* c.562G>T COSV100602134 Tier2 1 / 104
chr14:95590927 C A 10 / 29 p.E328* c.982G>T COSV58618447 Tier2 1 / 104
chr14:95583017 G A 12 / 29 p.R509* c.1525C>T COSV58621515 Tier2 1 / 104
chr14:95582041 G A 13 / 29 p.R624* c.1870C>T   Tier2 1 / 104
chr14:95577677 G A 16 / 29 p.R745* c.2233C>T COSV58628988 Tier2 1 / 104
chr14:95574777 C A 17 / 29 p.G774* c.2320G>T COSV100601607 Tier2 1 / 104
chr14:95570234 C A 23 / 29 p.E1167* c.3499G>T   Tier2 1 / 104
chr14:95562660 C A 25 / 29 p.E1533* c.4597G>T   Tier2 1 / 104
chr14:95562954 C A 25 / 29 p.E1435* c.4303G>T   Tier2 1 / 104
chr14:95560464 C T 26 / 29 p.D1709N c.5125G>A COSV58615449 Tier1 1 / 104
chr14:95560476 C A 26 / 29 p.E1705* c.5113G>T   Tier2 1 / 104