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DNMT3A

Basic information

Official gene symbol
DNA methyltransferase 3 alpha
Conventional gene symbol
DNMT3A2, HESJAS, M.HsaIIIA, TBRS
Classification
Oncogene / Tumor suppressor gene
Official gene ID
1788(Refseq)
1788 (KEGG)
Transcript ID
NM_175629
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
2p23.3 (chr2:25457148..25536853, complement)
Protein length
912

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr2:25469081 C CTTCCGGGGCTT 11 / 23 p.T461fs c.1366_1376dupAAGCCCCGGAA   Tier2 1 / 86
chr2:25468195 CA C 13 / 23 p.C494fs c.1480delT   Tier2 1 / 86
chr2:25467072 C T 15 / 23 p.W601* c.1803G>A COSV53046142 Tier2 1 / 86
chr2:25467083 G A 15 / 23 p.R598* c.1792C>T COSV53039812 Tier2 2 / 86
chr2:25457242 C T 23 / 23 p.R882H c.2645G>A COSV53036153 Tier1 1 / 86