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EGFR

Basic information

Official gene symbol
epidermal growth factor receptor
Conventional gene symbol
ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
Classification
Oncogene
Official gene ID
1956(Refseq)
1956 (KEGG)
Transcript ID
NM_005228
Functional classification
Tumor growth and progression
Signaling pathway
RTK
Chromosomal location
7p11.2 (chr7:55086971..55273310)
Protein length
1,210

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr7:55211080 G A 3 / 28 p.R108K c.323G>A COSV51766433 Tier1 1 / 355
chr7:55221722 G T 7 / 28 p.D256Y c.766G>T COSV51855357 Tier2 1 / 355
chr7:55221743 A C 7 / 28 p.T263P c.787A>C COSV51768130 Tier1 1 / 355
chr7:55221821 G A 7 / 28 p.A289T c.865G>A COSV51770322 Tier2 1 / 355
chr7:55221822 C A 7 / 28 p.A289D c.866C>A COSV51768139 Tier2 1 / 355
chr7:55221822 C T 7 / 28 p.A289V c.866C>T COSV51765841 Tier1 1 / 355
chr7:55223621 G A 8 / 28 p.E330K c.988G>A COSV51831642 Tier1 1 / 355
chr7:55233037 C T 15 / 28 p.P596L c.1787C>T COSV51779162 Tier2 2 / 355
chr7:55233043 G T 15 / 28 p.G598V c.1793G>T COSV51769031 Tier1 2 / 355
chr7:55240690 C G 17 / 28 p.S645C c.1934C>G COSV51772147 Tier2 1 / 355
chr7:55241677 G A 18 / 28 p.E709K c.2125G>A COSV51767260 Tier1 4 / 355
chr7:55241678 A C 18 / 28 p.E709A c.2126A>C COSV51772956 Tier1 2 / 355
chr7:55241678 A T 18 / 28 p.E709V c.2126A>T COSV51766584 Tier2 1 / 355
chr7:55241678 A G 18 / 28 p.E709G c.2126A>G COSV51765252 Tier2 3 / 355
chr7:55241707 G A 18 / 28 p.G719S c.2155G>A COSV51767289 Tier1 2 / 355
chr7:55241707 G T 18 / 28 p.G719C c.2155G>T COSV51766606 Tier1 1 / 355
chr7:55241708 G C 18 / 28 p.G719A c.2156G>C COSV51769339 Tier1 10 / 355
chr7:55241708 G A 18 / 28 p.G719D c.2156G>A COSV51779524 Tier2 1 / 355
chr7:55241726 C T 18 / 28 p.T725M c.2174C>T COSV51779794 Tier2 1 / 355
chr7:55242462 CAAGGAATTAAGAG C 19 / 28 p.E746fs c.2236_2248delGAATTAAGAGAAG   Tier1 1 / 355
chr7:55242463 AAGGAATTAAGAGAAGCAAC A 19 / 28 p.K745fs c.2235_2253delGGAATTAAGAGAAGCAACA   Tier1 1 / 355
chr7:55242464 AGGAATTAAGAGAAGC A 19 / 28 p.E746_A750del c.2235_2249delGGAATTAAGAGAAGC COSV51765119 Tier1 48 / 355
chr7:55242464 AGGAATTAAGAGAAGCAAC A 19 / 28 p.E746_T751del c.2235_2252delGGAATTAAGAGAAGCAAC COSV51810835 Tier1 1 / 355
chr7:55242465 GGAATTAAGAGAAGCA G 19 / 28 p.E746_A750del c.2236_2250delGAATTAAGAGAAGCA COSV51765066 Tier1 23 / 355
chr7:55242466 GAATTAAGAGAAGC G 19 / 28 p.L747fs c.2239_2251delTTAAGAGAAGCAA   Tier1 1 / 355
chr7:55242466 GAATTAAGAGAAGCAACA G 19 / 28 p.E746fs c.2237_2253delAATTAAGAGAAGCAACA   Tier1 2 / 355
chr7:55242466 GAATTAAGAGAAGCAA G 19 / 28 p.E746_T751delinsA c.2237_2251delAATTAAGAGAAGCAA COSV51769364 Tier1 1 / 355
chr7:55242467 AATTAAGAGAAGC A 19 / 28 p.L747_A750del c.2239_2250delTTAAGAGAAGCA COSV99289022 Tier1 3 / 355
chr7:55242467 AATTAAGAGAAGCAAC A 19 / 28 p.L747_T751del c.2240_2254delTAAGAGAAGCAACAT COSV51766247 Tier1 8 / 355
chr7:55242468 ATTAAGAGAAG A 19 / 28 p.L747fs c.2239_2248delTTAAGAGAAG   Tier1 1 / 355
chr7:55242469 TTAAGAGAAGCAACATCTC T 19 / 28 p.L747_P753delinsS c.2240_2257delTAAGAGAAGCAACATCTC COSV51767961 Tier1 12 / 355
chr7:55242481 ACATCT A 19 / 28 p.S752fs c.2253_2257delATCTC COSV51857889 Tier1 1 / 355
chr7:55242482 CATCTCCGAAAGCCAACAAGGAAAT C 19 / 28 p.S752_I759del c.2253_2276delATCTCCGAAAGCCAACAAGGAAAT COSV51766231 Tier1 2 / 355
chr7:55242483 ATCTCC A 19 / 28 p.S752fs c.2254_2258delTCTCC   Tier1 1 / 355
chr7:55242484 TCTCCGAAA T 19 / 28 p.S752fs c.2255_2262delCTCCGAAA   Tier1 1 / 355
chr7:55242485 C A 19 / 28 p.S752Y c.2255C>A COSV51866106 Tier2 1 / 355
chr7:55242486 TC T 19 / 28 p.P753fs c.2258delC   Tier1 2 / 355
chr7:55242490 A G 19 / 28 p.K754E c.2260A>G COSV51830809 Tier2 1 / 355
chr7:55248998 A ATGGCCAGCG 20 / 28 p.A767_V769dup c.2300_2308dupCCAGCGTGG COSV51766549 Tier1 7 / 355
chr7:55249002 C CCAGCGTGGA 20 / 28 p.S768_D770dup c.2303_2311dupGCGTGGACA COSV51774688 Tier1 2 / 355
chr7:55249005 G T 20 / 28 p.S768I c.2303G>T COSV51768106 Tier1 3 / 355
chr7:55249007 G A 20 / 28 p.V769M c.2305G>A COSV51802272 Tier2 1 / 355
chr7:55249010 G GACAACCCCC 20 / 28 p.N771_H773dup c.2311_2319dupAACCCCCAC COSV51772596 Tier1 1 / 355
chr7:55249011 A ACAACCCCCC 20 / 28 p.P772_H773insPNP c.2317_2318insCCAACCCCC   Tier1 1 / 355
chr7:55249017 C CCCA 20 / 28 p.H773dup c.2317_2319dupCAC COSV51781591 Tier1 1 / 355
chr7:55249020 A T 20 / 28 p.H773L c.2318A>T COSV51792805 Tier1 1 / 355
chr7:55249029 G A 20 / 28 p.R776H c.2327G>A COSV51780730 Tier2 1 / 355
chr7:55249071 C T 20 / 28 p.T790M c.2369C>T COSV51765492 Tier1 1 / 355
chr7:55259515 T G 21 / 28 p.L858R c.2573T>G COSV51765161 Tier1 119 / 355
chr7:55259524 T A 21 / 28 p.L861Q c.2582T>A COSV51766344 Tier1 6 / 355
chr7:55259554 C G 21 / 28 p.A871G c.2612C>G COSV51774247 Tier2 1 / 355