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ERBB2

Basic information

Official gene symbol
erb-b2 receptor tyrosine kinase 2
Conventional gene symbol
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Classification
Oncogene
Official gene ID
2064(Refseq)
2064 (KEGG)
Transcript ID
NM_004448
Functional classification
Tumor growth and progression
Signaling pathway
RTK
Chromosomal location
17q12 (chr17:37856492..37884297)
Protein length
1,255

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr17:37866626 G A 7 / 27 p.E265K c.793G>A COSV54078375 Tier2 1 / 163
chr17:37868208 C T 8 / 27 p.S310F c.929C>T COSV54062198 Tier1 9 / 163
chr17:37868208 C A 8 / 27 p.S310Y c.929C>A COSV54062802 Tier1 2 / 163
chr17:37879658 G A 17 / 27 p.R678Q c.2033G>A COSV54062926 Tier1 20 / 163
chr17:37879903 C T 18 / 27 p.T733I c.2198C>T COSV54064293 Tier2 1 / 163
chr17:37880220 T C 19 / 27 p.L755S c.2264T>C COSV54062780 Tier1 7 / 163
chr17:37880261 G C 19 / 27 p.D769H c.2305G>C COSV54062425 Tier1 2 / 163
chr17:37880981 A AGCATACGTGATG 20 / 27 p.A775_G776insYVMA c.2313_2324dupATACGTGATGGC COSV54062409 Tier1 3 / 163
chr17:37880997 G GTTT 20 / 27 p.G776delinsVC c.2326_2327insTTT COSV54064477 Tier1 1 / 163
chr17:37880997 G GTGT 20 / 27 p.G776delinsVC c.2326_2327insTGT COSV54064203 Tier1 1 / 163
chr17:37880998 G T 20 / 27 p.G776V c.2327G>T COSV54062853 Tier1 2 / 163
chr17:37881000 G T 20 / 27 p.V777L c.2329G>T COSV54062767 Tier1 11 / 163
chr17:37881000 G C 20 / 27 p.V777L c.2329G>C COSV54062385 Tier1 2 / 163
chr17:37881332 G A 21 / 27 p.V842I c.2524G>A COSV54062791 Tier1 8 / 163
chr17:37881392 A G 21 / 27 p.T862A c.2584A>G COSV54062276 Tier1 1 / 163
chr17:37881440 C T 21 / 27 p.H878Y c.2632C>T COSV54066178 Tier2 1 / 163