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ERBB3

Basic information

Official gene symbol
erb-b2 receptor tyrosine kinase 3
Conventional gene symbol
ErbB-3, FERLK, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Classification
Oncogene
Official gene ID
2065(Refseq)
2065 (KEGG)
Transcript ID
NM_001982
Functional classification
Tumor growth and progression
Signaling pathway
RTK
Chromosomal location
12q13.2 (chr12:56474085..56495839)
Protein length
1,342

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr12:56478854 G A 3 / 28 p.V104M c.310G>A COSV57246465 Tier1 13 / 153
chr12:56478854 G T 3 / 28 p.V104L c.310G>T COSV57246387 Tier2 5 / 153
chr12:56481660 C T 6 / 28 p.A232V c.695C>T COSV57246789 Tier1 7 / 153
chr12:56481922 G A 7 / 28 p.G284R c.850G>A COSV57246350 Tier1 5 / 153
chr12:56482341 G T 8 / 28 p.D297Y c.889G>T COSV57247504 Tier2 3 / 153
chr12:56490980 A G 20 / 28 p.Q809R c.2426A>G COSV57250012 Tier1 1 / 153
chr12:56492633 A G 23 / 28 p.E928G c.2783A>G COSV57248104 Tier1 9 / 153