ERBB4

Basic information

Official gene symbol: erb-b2 receptor tyrosine kinase 4
Conventional gene symbol: ALS19, HER4, p180erbB4
Classification: Oncogene / Tumor suppressor gene
Official gene ID: 2066(Refseq)

2066 (KEGG)
Transcript ID: NM_005235

Functional classification: Tumor growth and progression
Signaling pathway: RTK
Chromosomal location: 2q34 (chr2:212248340..213403254, complement)
Protein length: 1,308

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19)	Reference	Variant	Exon	Amino Acid change	Coding DNA change	COSMIC (v92)	Classification	No. of Samples
chr2:212570064	G	A	10 / 28	p.R393W	c.1177C>T	COSV53532907	Tier2	2 / 187
chr2:212537975	G	A	14 / 28	p.R544W	c.1630C>T	COSV53516478	Tier1	2 / 187
chr2:212248444	G	A	28 / 28	p.R1275W	c.3823C>T	COSV61470692	Tier1	2 / 187