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ERCC4

Basic information

Official gene symbol
ERCC excision repair 4, endonuclease catalytic subunit
Conventional gene symbol
ERCC11, FANCQ, RAD1, XFEPS, XPF
Classification
Tumor suppressor gene
Official gene ID
2072(Refseq)
2072 (KEGG)
Transcript ID
NM_005236
Functional classification
Genome maintenance
Signaling pathway
Core DNA Damage Response
Chromosomal location
16p13.12 (chr16:14014023..14042204)
Protein length
916

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr16:14015946 CAA C 2 / 11 p.N90fs c.268_269delAA   Tier2 1 / 65
chr16:14026133 G T 6 / 11 p.E365* c.1093G>T   Tier2 1 / 65
chr16:14029335 C T 8 / 11 p.R516* c.1546C>T COSV61311266 Tier2 2 / 65
chr16:14041593 G T 11 / 11 p.G714* c.2140G>T   Tier2 1 / 65