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EZH2
Basic information
- Official gene symbol
-
enhancer of zeste 2 polycomb repressive complex 2 subunit
- Conventional gene symbol
-
ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS, WVS2
- Classification
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Oncogene / Tumor suppressor gene
- Official gene ID
- Transcript ID
- Functional classification
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Epigenetic regulation
- Signaling pathway
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Epigenetic modification
- Chromosomal location
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7q36.1 (chr7:148504738..148544390, complement)
- Protein length
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746
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr7:148526883 | G | A | 5 / 20 | p.Q141* | c.421C>T | Tier2 | 1 / 59 | |
| chr7:148524269 | C | A | 7 / 20 | p.E239* | c.715G>T | Tier2 | 1 / 59 | |
| chr7:148515008 | C | A | 10 / 20 | p.E396* | c.1186G>T | COSV57450175 | Tier2 | 1 / 59 |
| chr7:148513849 | C | A | 12 / 20 | p.E473* | c.1417G>T | COSV57449564 | Tier2 | 1 / 59 |