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FAS

Basic information

Official gene symbol
Fas cell surface death receptor
Conventional gene symbol
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Classification
Tumor suppressor gene
Official gene ID
355(Refseq)
355 (KEGG)
Transcript ID
NM_000043
Functional classification
Cell death
Signaling pathway
Apoptosis
Chromosomal location
10q23.31 (chr10:90750634..90774207)
Protein length
335

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr10:90773119 T A 8 / 9 p.L224* c.671T>A   Tier2 1 / 34
chr10:90773119 T G 8 / 9 p.L224* c.671T>G COSV58238298 Tier2 1 / 34
chr10:90773947 C T 9 / 9 p.R250* c.748C>T COSV58238780 Tier2 1 / 34
chr10:90773965 G T 9 / 9 p.E256* c.766G>T   Tier2 1 / 34
chr10:90774013 G T 9 / 9 p.E272* c.814G>T   Tier2 1 / 34
chr10:90774064 G T 9 / 9 p.E289* c.865G>T   Tier2 1 / 34