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FAT1

Basic information

Official gene symbol
FAT atypical cadherin 1
Conventional gene symbol
CDHF7, CDHR8, FAT, ME5, hFat1
Classification
Tumor suppressor gene
Official gene ID
2195(Refseq)
2195 (KEGG)
Transcript ID
NM_005245
Functional classification
Differentiation
Signaling pathway
WNT
Chromosomal location
4q35.2 (chr4:187509746..187630981, complement)
Protein length
4,588

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr4:187627774 G A 2 / 27 p.R1070* c.3208C>T COSV71674659 Tier2 4 / 310
chr4:187628095 T A 2 / 27 p.R963* c.2887A>T   Tier2 1 / 310
chr4:187628101 G A 2 / 27 p.Q961* c.2881C>T COSV101498593 Tier2 2 / 310
chr4:187628266 G A 2 / 27 p.Q906* c.2716C>T COSV71675913 Tier2 1 / 310
chr4:187628547 AC A 2 / 27 p.V812fs c.2434delG   Tier2 1 / 310
chr4:187628809 G A 2 / 27 p.Q725* c.2173C>T COSV71675113 Tier2 1 / 310
chr4:187628904 A C 2 / 27 p.L693* c.2078T>G   Tier2 1 / 310
chr4:187629163 C A 2 / 27 p.E607* c.1819G>T   Tier2 1 / 310
chr4:187629175 G A 2 / 27 p.Q603* c.1807C>T   Tier2 1 / 310
chr4:187629373 TCA T 2 / 27 p.L536fs c.1607_1608delTG   Tier2 1 / 310
chr4:187629454 AC A 2 / 27 p.F510fs c.1527delG   Tier2 1 / 310
chr4:187629687 GCTGCC G 2 / 27 p.Q430fs c.1290_1294delGGCAG   Tier2 1 / 310
chr4:187629850 C A 2 / 27 p.E378* c.1132G>T   Tier2 1 / 310
chr4:187629986 G C 2 / 27 p.Y332* c.996C>G   Tier2 1 / 310
chr4:187630037 A T 2 / 27 p.Y315* c.945T>A   Tier2 1 / 310
chr4:187630162 C CA 2 / 27 p.A274fs c.819dupT COSV101499379 Tier2 1 / 310
chr4:187630186 C A 2 / 27 p.E266* c.796G>T   Tier2 1 / 310
chr4:187630328 A C 2 / 27 p.Y218* c.654T>G   Tier2 1 / 310
chr4:187630411 G A 2 / 27 p.R191* c.571C>T COSV71672617 Tier2 1 / 310
chr4:187630588 G A 2 / 27 p.R132* c.394C>T COSV71671964 Tier2 2 / 310
chr4:187630711 C A 2 / 27 p.G91* c.271G>T   Tier2 1 / 310
chr4:187630797 T TAAAC 2 / 27 p.Y62fs c.181_184dupGTTT   Tier2 1 / 310
chr4:187630906 G A 2 / 27 p.R26* c.76C>T   Tier2 1 / 310
chr4:187584647 ACCTC A 3 / 27 p.E1128fs c.3382_3385delGAGG   Tier2 1 / 310
chr4:187584747 G A 3 / 27 p.R1096* c.3286C>T COSV71672426 Tier2 1 / 310
chr4:187557756 C A 5 / 27 p.E1319* c.3955G>T   Tier2 2 / 310
chr4:187557924 C A 5 / 27 p.E1263* c.3787G>T   Tier2 1 / 310
chr4:187557927 G A 5 / 27 p.R1262* c.3784C>T COSV71675829(SNP) Tier2 1 / 310
chr4:187557215 CCA C 6 / 27 p.V1382fs c.4145_4146delTG   Tier2 1 / 310
chr4:187554945 T A 7 / 27 p.K1406* c.4216A>T   Tier2 1 / 310
chr4:187549689 CAGAAGTAT C 8 / 27 p.Y1515fs c.4544_4551delATACTTCT   Tier2 1 / 310
chr4:187549821 C A 8 / 27 p.E1474* c.4420G>T   Tier2 1 / 310
chr4:187549406 AC A 9 / 27 p.V1571fs c.4711delG   Tier2 1 / 310
chr4:187549427 G GCGGTGAACCA 9 / 27 p.A1564fs c.4681_4690dupTGGTTCACCG   Tier2 1 / 310
chr4:187539690 C A 10 / 27 p.E2684* c.8050G>T COSV71672478 Tier2 1 / 310
chr4:187539695 G GA 10 / 27 p.S2682fs c.8044dupT   Tier2 1 / 310
chr4:187539951 G A 10 / 27 p.R2597* c.7789C>T COSV71672084 Tier2 4 / 310
chr4:187540163 TG T 10 / 27 p.H2526fs c.7576delC   Tier2 1 / 310
chr4:187540464 G A 10 / 27 p.Q2426* c.7276C>T   Tier2 1 / 310
chr4:187540481 G C 10 / 27 p.S2420* c.7259C>G   Tier2 2 / 310
chr4:187540528 AGG A 10 / 27 p.P2404fs c.7210_7211delCC   Tier2 1 / 310
chr4:187540614 CAA C 10 / 27 p.I2375fs c.7124_7125delTT   Tier2 1 / 310
chr4:187540779 G A 10 / 27 p.Q2321* c.6961C>T COSV71675559 Tier2 1 / 310
chr4:187540784 G C 10 / 27 p.S2319* c.6956C>G COSV71674364 Tier2 1 / 310
chr4:187541295 C A 10 / 27 p.E2149* c.6445G>T COSV71671772 Tier2 2 / 310
chr4:187542065 GTTGGTAACAAAAGAGATGCT G 10 / 27 p.E1885fs c.5655_5674delAGCATCTCTTTTGTTACCAA   Tier2 1 / 310
chr4:187542162 C A 10 / 27 p.E1860* c.5578G>T   Tier2 1 / 310
chr4:187542318 C CA 10 / 27 p.V1808fs c.5421dupT   Tier2 1 / 310
chr4:187542332 G C 10 / 27 p.S1803* c.5408C>G COSV71672193 Tier2 1 / 310
chr4:187542494 GTATTAGTGGACAAACCAGCCATGTTAGTTCCTTGTAT G 10 / 27 p.I1737fs c.5209_5245delATACAAGGAACTAACATGGCTGGTTTGTCCACTAATA   Tier2 1 / 310
chr4:187542870 C A 10 / 27 p.E1624* c.4870G>T COSV101499639 Tier2 1 / 310
chr4:187538220 G C 11 / 27 p.S3005* c.9014C>G COSV71673041 Tier2 1 / 310
chr4:187538272 T A 11 / 27 p.K2988* c.8962A>T   Tier2 1 / 310
chr4:187535394 G C 12 / 27 p.Y3060* c.9180C>G   Tier2 1 / 310
chr4:187534453 A AG 13 / 27 p.V3092fs c.9272dupC   Tier2 1 / 310
chr4:187532590 G T 14 / 27 p.S3268* c.9803C>A   Tier2 1 / 310
chr4:187531111 TGTTAG T 15 / 27 p.L3303fs c.9907_9911delCTAAC   Tier2 1 / 310
chr4:187530408 G A 16 / 27 p.Q3379* c.10135C>T COSV104716925 Tier2 1 / 310
chr4:187530421 AATTG A 16 / 27 p.S3373fs c.10118_10121delCAAT   Tier2 1 / 310
chr4:187527274 TGACATCG T 17 / 27 p.D3432fs c.10293_10299delCGATGTC   Tier2 1 / 310
chr4:187525541 AGT A 18 / 27 p.L3512fs c.10536_10537delAC   Tier2 1 / 310
chr4:187524330 C A 19 / 27 p.E3784* c.11350G>T   Tier2 1 / 310
chr4:187524567 G A 19 / 27 p.Q3705* c.11113C>T COSV71673051 Tier2 1 / 310
chr4:187524720 C A 19 / 27 p.E3654* c.10960G>T COSV71674882 Tier2 1 / 310
chr4:187524787 G GA 19 / 27 p.R3632fs c.10892dupT   Tier2 1 / 310
chr4:187524906 CAG C 19 / 27 p.S3591fs c.10772_10773delCT   Tier2 1 / 310
chr4:187524917 TTGTC T 19 / 27 p.D3587fs c.10759_10762delGACA   Tier2 1 / 310
chr4:187522425 C A 21 / 27 p.E3880* c.11638G>T   Tier2 1 / 310
chr4:187522495 GGTCA G 21 / 27 p.L3855fs c.11564_11567delTGAC   Tier2 1 / 310
chr4:187522557 C A 21 / 27 p.G3836* c.11506G>T   Tier2 1 / 310
chr4:187521157 C A 22 / 27 p.E4000* c.11998G>T   Tier2 1 / 310
chr4:187521224 CA C 22 / 27 p.M3977fs c.11930delT   Tier2 1 / 310
chr4:187521370 G A 22 / 27 p.Q3929* c.11785C>T COSV71672375 Tier2 1 / 310
chr4:187521442 G A 22 / 27 p.Q3905* c.11713C>T COSV71676602 Tier2 2 / 310
chr4:187521451 G A 22 / 27 p.Q3902* c.11704C>T COSV71673132 Tier2 1 / 310
chr4:187521478 C A 22 / 27 p.G3893* c.11677G>T   Tier2 1 / 310
chr4:187519258 G GC 23 / 27 p.A4042fs c.12124dupG   Tier2 1 / 310
chr4:187519275 A T 23 / 27 p.Y4036* c.12108T>A   Tier2 1 / 310
chr4:187518840 C A 24 / 27 p.E4122* c.12364G>T   Tier2 1 / 310
chr4:187518030 C A 25 / 27 p.G4222* c.12664G>T   Tier2 1 / 310
chr4:187518311 ATATCACTCTG A 25 / 27 p.Q4125fs c.12373_12382delCAGAGTGATA   Tier2 1 / 310
chr4:187510318 C A 27 / 27 p.E4399* c.13195G>T   Tier2 1 / 310