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FBXW7

Basic information

Official gene symbol
F-box and WD repeat domain containing 7
Conventional gene symbol
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Classification
Tumor suppressor gene
Official gene ID
55294(Refseq)
55294 (KEGG)
Transcript ID
NM_033632
Functional classification
Protein homeostasis
Signaling pathway
Protein homeostasis
Chromosomal location
4q31.3 (chr4:153244033..153332955, complement)
Protein length
707

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr4:153332598 G A 2 / 12 p.Q120* c.358C>T COSV55898137 Tier2 2 / 368
chr4:153332655 CT C 2 / 12 p.D101fs c.300delA   Tier2 1 / 368
chr4:153332681 G C 2 / 12 p.S92* c.275C>G COSV104386633 Tier2 1 / 368
chr4:153332699 G T 2 / 12 p.S86* c.257C>A COSV99905192 Tier2 2 / 368
chr4:153332713 ATTGTTTTCTT A 2 / 12 p.E78fs c.233_242delAAGAAAACAA   Tier2 1 / 368
chr4:153332733 C A 2 / 12 p.G75* c.223G>T   Tier2 1 / 368
chr4:153332736 G A 2 / 12 p.Q74* c.220C>T   Tier2 1 / 368
chr4:153332769 C A 2 / 12 p.E63* c.187G>T   Tier2 1 / 368
chr4:153332826 G A 2 / 12 p.Q44* c.130C>T COSV99899260 Tier2 1 / 368
chr4:153332832 G A 2 / 12 p.Q42* c.124C>T   Tier2 1 / 368
chr4:153332862 G A 2 / 12 p.Q32* c.94C>T   Tier2 1 / 368
chr4:153332916 G A 2 / 12 p.R14* c.40C>T COSV55920408 Tier2 1 / 368
chr4:153332919 G A 2 / 12 p.R13* c.37C>T COSV55916781 Tier2 1 / 368
chr4:153271204 C A 3 / 12 p.E192* c.574G>T   Tier2 1 / 368
chr4:153271206 G C 3 / 12 p.S191* c.572C>G COSV99656056 Tier2 1 / 368
chr4:153271214 G T 3 / 12 p.C188* c.564C>A   Tier2 1 / 368
chr4:153271249 C A 3 / 12 p.E177* c.529G>T   Tier2 1 / 368
chr4:153268097 C T 4 / 12 p.W237* c.711G>A COSV55907222 Tier2 1 / 368
chr4:153268138 G A 4 / 12 p.R224* c.670C>T COSV55899023 Tier2 2 / 368
chr4:153268150 G A 4 / 12 p.Q220* c.658C>T COSV55936792 Tier2 1 / 368
chr4:153258970 G T 5 / 12 p.S282* c.845C>A COSV55899012 Tier2 3 / 368
chr4:153258983 G A 5 / 12 p.R278* c.832C>T COSV55891638 Tier2 18 / 368
chr4:153258986 G A 5 / 12 p.Q277* c.829C>T COSV55917375 Tier2 1 / 368
chr4:153259011 CAT C 5 / 12 p.M268fs c.802_803delAT COSV55902937 Tier2 4 / 368
chr4:153259025 G A 5 / 12 p.Q264* c.790C>T COSV55916003 Tier2 1 / 368
chr4:153259070 T A 5 / 12 p.K249* c.745A>T   Tier2 1 / 368
chr4:153259079 C A 5 / 12 p.G246* c.736G>T   Tier2 1 / 368
chr4:153259084 C T 5 / 12 p.W244* c.731G>A COSV104381730 Tier2 1 / 368
chr4:153253743 CTTACCCTCT C 6 / 12 p.E328fs c.981_985+4delAGAGGGTAA   Tier2 1 / 368
chr4:153253751 C A 6 / 12 p.E328* c.982G>T   Tier2 1 / 368
chr4:153253789 G GC 6 / 12 p.A315fs c.943dupG   Tier2 1 / 368
chr4:153253791 CAAAATTCTCCAG C 6 / 12 p.Y310_L314delins* c.930_941delCTGGAGAATTTT   Tier2 1 / 368
chr4:153253806 GC G 6 / 12 p.R309fs c.926delG   Tier2 1 / 368
chr4:153253822 GC G 6 / 12 p.A304fs c.910delG   Tier2 1 / 368
chr4:153253843 TCCAGGAATGAAAG T 6 / 12 p.L293fs c.877_889delCTTTCATTCCTGG   Tier2 1 / 368
chr4:153253852 G T 6 / 12 p.S294* c.881C>A COSV99656421 Tier2 1 / 368
chr4:153253859 CAT C 6 / 12 p.Y291fs c.872_873delAT   Tier2 2 / 368
chr4:153251907 G A 7 / 12 p.R367* c.1099C>T COSV55891887 Tier2 14 / 368
chr4:153251954 C T 7 / 12 p.W351* c.1052G>A   Tier2 2 / 368
chr4:153250843 C T 8 / 12 p.W406* c.1217G>A   Tier2 1 / 368
chr4:153250877 C CT 8 / 12 p.V395fs c.1182dupA   Tier2 1 / 368
chr4:153250883 G A 8 / 12 p.R393* c.1177C>T COSV55892695 Tier2 10 / 368
chr4:153250931 T A 8 / 12 p.K377* c.1129A>T   Tier2 1 / 368
chr4:153249384 C T 9 / 12 p.R465H c.1394G>A COSV55891746 Tier2 30 / 368
chr4:153249385 G A 9 / 12 p.R465C c.1393C>T COSV55891008 Tier1 28 / 368
chr4:153249390 G GT 9 / 12 p.T463fs c.1387dupA   Tier2 1 / 368
chr4:153249424 C A 9 / 12 p.E452* c.1354G>T   Tier2 1 / 368
chr4:153249511 C T 9 / 12 p.G423R c.1267G>A COSV55902795 Tier2 1 / 368
chr4:153247160 G A 10 / 12 p.Q548* c.1642C>T COSV55910404 Tier2 1 / 368
chr4:153247165 G T 10 / 12 p.S546* c.1637C>A COSV99656643 Tier2 2 / 368
chr4:153247225 C T 10 / 12 p.W526* c.1577G>A COSV55924621 Tier2 1 / 368
chr4:153247288 C T 10 / 12 p.R505H c.1514G>A COSV55901126 Tier2 4 / 368
chr4:153247288 C A 10 / 12 p.R505L c.1514G>T COSV55908371 Tier1 4 / 368
chr4:153247289 G A 10 / 12 p.R505C c.1513C>T COSV55891274 Tier1 27 / 368
chr4:153247289 G T 10 / 12 p.R505S c.1513C>A COSV55898451 Tier2 3 / 368
chr4:153247289 G C 10 / 12 p.R505G c.1513C>G COSV55890969 Tier2 2 / 368
chr4:153247328 G A 10 / 12 p.Q492* c.1474C>T COSV55944219 Tier2 1 / 368
chr4:153247366 C T 10 / 12 p.R479Q c.1436G>A COSV55890822 Tier1 16 / 368
chr4:153247366 C G 10 / 12 p.R479P c.1436G>C COSV55894913 Tier2 2 / 368
chr4:153247366 C A 10 / 12 p.R479L c.1436G>T COSV55899054 Tier2 1 / 368
chr4:153247367 G C 10 / 12 p.R479G c.1435C>G COSV55894999 Tier2 2 / 368
chr4:153247367 G A 10 / 12 p.R479* c.1435C>T COSV55894141 Tier2 3 / 368
chr4:153245339 G A 11 / 12 p.Q618* c.1852C>T COSV55953735 Tier2 1 / 368
chr4:153245350 A T 11 / 12 p.L614* c.1841T>A   Tier2 1 / 368
chr4:153245486 C A 11 / 12 p.E569* c.1705G>T   Tier2 2 / 368
chr4:153245506 G T 11 / 12 p.S562* c.1685C>A COSV55891704 Tier2 1 / 368
chr4:153244091 C T 12 / 12 p.R689Q c.2066G>A COSV55900091 Tier2 1 / 368
chr4:153244124 G C 12 / 12 p.S678* c.2033C>G COSV55897853 Tier2 1 / 368
chr4:153244143 C CA 12 / 12 p.V672fs c.2013dupT   Tier2 1 / 368
chr4:153244184 C T 12 / 12 p.R658Q c.1973G>A COSV55905466 Tier2 2 / 368
chr4:153244185 G A 12 / 12 p.R658* c.1972C>T COSV55892162 Tier2 8 / 368
chr4:153244211 C T 12 / 12 p.W649* c.1946G>A COSV99654862 Tier2 1 / 368
chr4:153244266 G A 12 / 12 p.Q631* c.1891C>T   Tier2 1 / 368
chr4:153244287 G A 12 / 12 p.Q624* c.1870C>T   Tier2 1 / 368