Side Menu

FGFR2

Basic information

Official gene symbol
fibroblast growth factor receptor 2
Conventional gene symbol
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
Classification
Oncogene
Official gene ID
2263(Refseq)
2263 (KEGG)
Transcript ID
NM_000141
Functional classification
Tumor growth and progression
Signaling pathway
RTK
Chromosomal location
10q26.13 (chr10:123239371..123353331, complement)
Protein length
821

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr10:123279677 G C 7 / 18 p.S252W c.755C>G COSV60638319 Tier1 6 / 86
chr10:123274774 A G 9 / 18 p.C382R c.1144T>C COSV60638681 Tier1 1 / 86
chr10:123274777 A C 9 / 18 p.Y381D c.1141T>G   Tier1 2 / 86
chr10:123258034 A T 12 / 18 p.N549K c.1647T>A COSV60639738 Tier1 1 / 86
chr10:123258034 A C 12 / 18 p.N549K c.1647T>G COSV60638757 Tier1 1 / 86
chr10:123258035 T C 12 / 18 p.N549S c.1646A>G COSV60645338 Tier1 1 / 86
chr10:123258036 T G 12 / 18 p.N549H c.1645A>C COSV60640393 Tier1 2 / 86
chr10:123258070 C A 12 / 18 p.M537I c.1611G>T COSV60655080 Tier1 1 / 86
chr10:123247549 C T 14 / 18 p.A648T c.1942G>A COSV60650006 Tier1 3 / 86
chr10:123244913 C T 16 / 18 p.E731K c.2191G>A COSV60652082 Tier1 1 / 86