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GATA3

Basic information

Official gene symbol
GATA binding protein 3
Conventional gene symbol
HDR, HDRS
Classification
Oncogene / Tumor suppressor gene
Official gene ID
2625(Refseq)
2625 (KEGG)
Transcript ID
NM_002051
Functional classification
Transcriptional regulation
Signaling pathway
Transcriptional regulation
Chromosomal location
10p14 (chr10:8097619..8115986)
Protein length
443

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr10:8105964 G T 4 / 6 p.E262* c.784G>T   Tier2 1 / 108
chr10:8106006 C T 4 / 6 p.R276* c.826C>T   Tier2 1 / 108
chr10:8111475 C CA 5 / 6 p.T322fs c.962dupA COSV60515713 Tier2 1 / 108
chr10:8111495 C CTGGAGGA 5 / 6 p.R330fs c.982_988dupTGGAGGA COSV60516089 Tier2 1 / 108
chr10:8111534 C CT 5 / 6 p.C341fs c.1021dupT   Tier2 1 / 108
chr10:8111543 C CT 5 / 6 p.Y344fs c.1030dupT COSV60515810 Tier2 1 / 108
chr10:8111555 TC T 5 / 6 p.H348fs c.1042delC   Tier2 1 / 108
chr10:8115819 AGCTCGTTTAACCCGGCC A 6 / 6 p.S390fs c.1168_1184delTCGTTTAACCCGGCCGC   Tier2 1 / 108
chr10:8115870 ATC A 6 / 6 p.S407fs c.1219_1220delTC COSV60516409 Tier2 1 / 108
chr10:8115873 TC T 6 / 6 p.S407fs c.1220delC COSV60516876 Tier2 1 / 108
chr10:8115874 C CA 6 / 6 p.P408fs c.1220_1221insA COSV60515158 Tier2 1 / 108
chr10:8115919 TGCACCCGCCATCCA T 6 / 6 p.H423fs c.1268_1281delACCCGCCATCCAGC   Tier2 1 / 108
chr10:8115982 G GT 6 / 6 p.*444fs c.1330dupT COSV60520243 Tier2 1 / 108