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HRAS
Basic information
- Official gene symbol
-
HRas proto-oncogene, GTPase
- Conventional gene symbol
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C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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MAPK
- Chromosomal location
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11p15.5 (chr11:532636..534322, complement)
- Protein length
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189
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr11:534285 | C | A | 2 / 5 | p.G13V | c.38G>T | COSV54237051 | Tier2 | 3 / 56 |
| chr11:534285 | C | T | 2 / 5 | p.G13D | c.38G>A | COSV54237021 | Tier2 | 2 / 56 |
| chr11:534286 | C | G | 2 / 5 | p.G13R | c.37G>C | COSV54236651 | Tier1 | 4 / 56 |
| chr11:534286 | C | A | 2 / 5 | p.G13C | c.37G>T | COSV54241641 | Tier1 | 1 / 56 |
| chr11:534288 | C | T | 2 / 5 | p.G12D | c.35G>A | COSV54236774 | Tier1 | 1 / 56 |
| chr11:534289 | C | T | 2 / 5 | p.G12S | c.34G>A | COSV54237299 | Tier1 | 9 / 56 |
| chr11:533873 | C | G | 3 / 5 | p.Q61H | c.183G>C | COSV54239883 | Tier2 | 1 / 56 |
| chr11:533874 | T | C | 3 / 5 | p.Q61R | c.182A>G | COSV54236691 | Tier1 | 4 / 56 |
| chr11:533874 | T | A | 3 / 5 | p.Q61L | c.182A>T | COSV54236656 | Tier1 | 4 / 56 |
| chr11:533875 | G | T | 3 / 5 | p.Q61K | c.181C>A | COSV54236740 | Tier1 | 1 / 56 |
| chr11:533881 | C | T | 3 / 5 | p.A59T | c.175G>A | COSV54244375 | Tier1 | 1 / 56 |
| chr11:533552 | C | A | 4 / 5 | p.K117N | c.351G>T | COSV54237107 | Tier2 | 1 / 56 |