IDH2

Basic information

Official gene symbol: isocitrate dehydrogenase (NADP(+)) 2
Conventional gene symbol: D2HGA2, ICD-M, IDHM, IDPM, mNADP-IDH
Classification: Oncogene
Official gene ID: 3418(Refseq)

3418 (KEGG)
Transcript ID: NM_002168

Functional classification: Epigenetic regulation
Signaling pathway: Epigenetic modification
Chromosomal location: 15q26.1 (chr15:90627498..90645622, complement)
Protein length: 452

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19)	Reference	Variant	Exon	Amino Acid change	Coding DNA change	COSMIC (v92)	Classification	No. of Samples
chr15:90631838	C	T	4 / 11	p.R172K	c.515G>A	COSV57468734	Tier1	1 / 37
chr15:90631839	T	A	4 / 11	p.R172W	c.514A>T	COSV57468942	Tier2	1 / 37
chr15:90631934	C	T	4 / 11	p.R140Q	c.419G>A	COSV57468751	Tier1	1 / 37