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INPP4B

Basic information

Official gene symbol
inositol polyphosphate-4-phosphatase type II B
Classification
Tumor suppressor gene
Official gene ID
8821(Refseq)
8821 (KEGG)
Transcript ID
NM_003866
Functional classification
Tumor growth and progression
Signaling pathway
PI3K/Akt/mTOR
Chromosomal location
4q31.21 (chr4:142949935..143352412, complement)
Protein length
924

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr4:143159099 G A 13 / 27 p.R252* c.754C>T COSV99523543 Tier2 2 / 69
chr4:143159109 C T 13 / 27 p.W248* c.744G>A COSV99525563 Tier2 1 / 69
chr4:143130127 G A 14 / 27 p.R297* c.889C>T COSV53710700 Tier2 1 / 69
chr4:143130163 C A 14 / 27 p.E285* c.853G>T COSV53716655 Tier2 2 / 69
chr4:143033703 CAG C 23 / 27 p.L756fs c.2266_2267delCT   Tier2 1 / 69
chr4:143029339 CAAACCTACAAACAG C 24 / 27 p.F760fs c.2277-10_2280delCTGTTTGTAGGTTT   Tier2 1 / 69
chr4:143007320 C A 25 / 27 p.E822* c.2464G>T   Tier2 1 / 69