Side Menu

KDM5C

Basic information

Official gene symbol
lysine demethylase 5C
Conventional gene symbol
DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
Classification
Tumor suppressor gene
Official gene ID
8242(Refseq)
8242 (KEGG)
Transcript ID
NM_004187
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
Xp11.22 (chrX:53222149..53254071, complement)
Protein length
1,560

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chrX:53245033 C A 7 / 26 p.E303* c.907G>T   Tier2 1 / 91
chrX:53240687 C A 10 / 26 p.E465* c.1393G>T   Tier2 1 / 91
chrX:53228051 C A 16 / 26 p.E755* c.2263G>T   Tier2 1 / 91
chrX:53227706 G A 17 / 26 p.R828* c.2482C>T COSV64765067 Tier2 1 / 91
chrX:53227751 GCAGCAGCTCACTATTAGGAAACCTCCGCT G 17 / 26 p.E803fs c.2408_2436delAGCGGAGGTTTCCTAATAGTGAGCTGCTG   Tier2 1 / 91
chrX:53226064 G A 19 / 26 p.R929* c.2785C>T COSV64765756 Tier2 1 / 91
chrX:53223890 C A 23 / 26 p.E1157* c.3469G>T   Tier2 1 / 91
chrX:53223899 C A 23 / 26 p.E1154* c.3460G>T COSV64764320 Tier2 1 / 91