Side Menu
KRAS
Basic information
- Official gene symbol
-
KRAS proto-oncogene, GTPase
- Conventional gene symbol
-
'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2
- Classification
-
Oncogene
- Official gene ID
- Transcript ID
- Functional classification
-
Tumor growth and progression
- Signaling pathway
-
MAPK
- Chromosomal location
-
12p12.1 (chr12:25368375..25398318, complement)
- Protein length
-
189
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr12:25398255 | G | T | 2 / 6 | p.Q22K | c.64C>A | COSV55526911 | Tier1 | 3 / 928 |
| chr12:25398262 | C | A | 2 / 6 | p.L19F | c.57G>T | COSV55502103 | Tier1 | 2 / 928 |
| chr12:25398279 | C | T | 2 / 6 | p.V14I | c.40G>A | COSV55501342 | Tier2 | 1 / 928 |
| chr12:25398281 | C | T | 2 / 6 | p.G13D | c.38G>A | COSV55497388 | Tier1 | 143 / 928 |
| chr12:25398281 | C | A | 2 / 6 | p.G13V | c.38G>T | COSV55522580 | Tier1 | 1 / 928 |
| chr12:25398282 | C | A | 2 / 6 | p.G13C | c.37G>T | COSV55497378 | Tier1 | 9 / 928 |
| chr12:25398282 | C | G | 2 / 6 | p.G13R | c.37G>C | COSV55502117 | Tier1 | 1 / 928 |
| chr12:25398284 | C | A | 2 / 6 | p.G12V | c.35G>T | COSV55497419 | Tier1 | 176 / 928 |
| chr12:25398284 | C | T | 2 / 6 | p.G12D | c.35G>A | COSV55497369 | Tier1 | 291 / 928 |
| chr12:25398284 | C | G | 2 / 6 | p.G12A | c.35G>C | COSV55497479 | Tier1 | 47 / 928 |
| chr12:25398285 | C | A | 2 / 6 | p.G12C | c.34G>T | COSV55497469 | Tier1 | 73 / 928 |
| chr12:25398285 | C | G | 2 / 6 | p.G12R | c.34G>C | COSV55497582 | Tier1 | 14 / 928 |
| chr12:25398285 | C | T | 2 / 6 | p.G12S | c.34G>A | COSV55497461 | Tier1 | 45 / 928 |
| chr12:25380238 | T | G | 3 / 6 | p.T74P | c.220A>C | COSV55722485 | Tier2 | 1 / 928 |
| chr12:25380275 | T | A | 3 / 6 | p.Q61H | c.183A>T | COSV55499223 | Tier1 | 6 / 928 |
| chr12:25380275 | T | G | 3 / 6 | p.Q61H | c.183A>C | COSV55498802 | Tier1 | 19 / 928 |
| chr12:25380276 | T | C | 3 / 6 | p.Q61R | c.182A>G | COSV55498739 | Tier1 | 4 / 928 |
| chr12:25380276 | T | A | 3 / 6 | p.Q61L | c.182A>T | COSV55504296 | Tier1 | 4 / 928 |
| chr12:25380279 | C | A | 3 / 6 | p.G60V | c.179G>T | COSV55708344 | Tier2 | 1 / 928 |
| chr12:25380282 | G | C | 3 / 6 | p.A59G | c.176C>G | COSV55604554 | Tier1 | 1 / 928 |
| chr12:25380283 | C | T | 3 / 6 | p.A59T | c.175G>A | COSV55499283 | Tier1 | 5 / 928 |
| chr12:25378561 | G | A | 4 / 6 | p.A146V | c.437C>T | COSV55498939 | Tier1 | 6 / 928 |
| chr12:25378562 | C | T | 4 / 6 | p.A146T | c.436G>A | COSV55501778 | Tier1 | 41 / 928 |
| chr12:25378562 | C | G | 4 / 6 | p.A146P | c.436G>C | COSV55541748 | Tier1 | 3 / 928 |
| chr12:25378647 | T | A | 4 / 6 | p.K117N | c.351A>T | COSV55504752 | Tier1 | 10 / 928 |
| chr12:25378647 | T | G | 4 / 6 | p.K117N | c.351A>C | COSV55545304 | Tier1 | 2 / 928 |