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LZTR1
Basic information
- Official gene symbol
-
leucine zipper like transcription regulator 1
- Conventional gene symbol
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BTBD29, LZTR-1, NS10, NS2, SWNTS2
- Classification
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Tumor suppressor gene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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MAPK
- Chromosomal location
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22q11.21, 22q11.1-q11.2 (chr22:21336661..21351637)
- Protein length
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840
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr22:21341837 | C | T | 4 / 21 | p.S122L | c.365C>T | COSV99301371 | Tier2 | 1 / 99 |
| chr22:21347143 | G | A | 11 / 21 | p.G404R | c.1210G>A | COSV53146242 | Tier2 | 1 / 99 |
| chr22:21348228 | C | T | 13 / 21 | p.Q457* | c.1369C>T | COSV53147900 | Tier2 | 1 / 99 |