Side Menu

MAP2K1

Basic information

Official gene symbol
mitogen-activated protein kinase kinase 1
Conventional gene symbol
CFC3, MAPKK1, MEK1, MEL, MKK1, PRKMK1
Classification
Oncogene
Official gene ID
5604(Refseq)
5604 (KEGG)
Transcript ID
NM_002755
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
15q22.31 (chr15:66679686..66782953)
Protein length
393

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr15:66727441 T C 2 / 11 p.F53L c.157T>C COSV61068605 Tier1 1 / 39
chr15:66727443 T G 2 / 11 p.F53L c.159T>G COSV61071940 Tier1 1 / 39
chr15:66727453 A G 2 / 11 p.K57E c.169A>G COSV61070134 Tier1 2 / 39
chr15:66727454 A C 2 / 11 p.K57T c.170A>C COSV61068437 Tier2 1 / 39
chr15:66727455 G T 2 / 11 p.K57N c.171G>T COSV61068581 Tier1 5 / 39
chr15:66727483 G A 2 / 11 p.D67N c.199G>A COSV61068427 Tier1 2 / 39
chr15:66729163 C T 3 / 11 p.P124L c.371C>T COSV61068422 Tier1 2 / 39
chr15:66729175 G A 3 / 11 p.G128D c.383G>A COSV61068347 Tier2 1 / 39
chr15:66737006 C A 5 / 11 p.L177M c.529C>A COSV61069932 Tier1 2 / 39
chr15:66774131 G A 6 / 11 p.E203K c.607G>A COSV61068654 Tier1 2 / 39