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MAP2K4

Basic information

Official gene symbol
mitogen-activated protein kinase kinase 4
Conventional gene symbol
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Classification
Oncogene / Tumor suppressor gene
Official gene ID
6416(Refseq)
6416 (KEGG)
Transcript ID
NM_003010
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
17p12 (chr17:11924204..12044577)
Protein length
399

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr17:11958227 T A 2 / 11 p.L46* c.137T>A   Tier2 1 / 62
chr17:11984670 CAG C 3 / 11 p.R75fs c.224_225delGA COSV62255578 Tier2 1 / 62
chr17:11984670 CAGAG C 3 / 11 p.E74fs c.222_225delGAGA COSV62260111 Tier2 1 / 62
chr17:11984707 G A 3 / 11 p.G85R c.253G>A COSV62256162 Tier1 1 / 62
chr17:11998919 G T 4 / 11 p.E141* c.421G>T COSV62255314 Tier2 1 / 62
chr17:11998958 C T 4 / 11 p.R154W c.460C>T COSV62256275 Tier1 1 / 62
chr17:12016631 ACT A 7 / 11 p.S257fs c.770_771delCT   Tier2 1 / 62
chr17:12028632 G A 8 / 11 p.A279T c.835G>A COSV62255655 Tier1 1 / 62
chr17:12028638 C T 8 / 11 p.R281* c.841C>T COSV62255065 Tier2 2 / 62
chr17:12032474 C T 9 / 11 p.R304* c.910C>T COSV62255527 Tier2 1 / 62
chr17:12032483 TATCCA T 9 / 11 p.Y307fs c.921_925delTCCAA   Tier2 1 / 62
chr17:12032489 A T 9 / 11 p.K309* c.925A>T   Tier2 1 / 62
chr17:12032541 C T 9 / 11 p.P326L c.977C>T COSV62256985 Tier2 2 / 62
chr17:12032592 T TG 9 / 11 p.F343fs c.1028_1029insG   Tier2 1 / 62