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MAP3K1

Basic information

Official gene symbol
mitogen-activated protein kinase kinase kinase 1
Conventional gene symbol
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
Classification
Oncogene / Tumor suppressor gene
Official gene ID
4214(Refseq)
4214 (KEGG)
Transcript ID
NM_005921
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
5q11.2 (chr5:56111401..56189507)
Protein length
1,512

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr5:56152566 C T 2 / 20 p.R208* c.622C>T COSV68125794 Tier2 1 / 106
chr5:56155699 CAG C 3 / 20 p.E265fs c.793_794delGA COSV99063982 Tier2 1 / 106
chr5:56155720 GAA G 3 / 20 p.R273fs c.816_817delAA COSV68126639 Tier2 1 / 106
chr5:56155724 AAG A 3 / 20 p.R273fs c.819_820delAG COSV68121778 Tier2 1 / 106
chr5:56155728 G GTT 3 / 20 p.S275fs c.822_823dupTT   Tier2 1 / 106
chr5:56160633 GAA G 4 / 20 p.E303fs c.909_910delAA   Tier2 1 / 106
chr5:56160643 GC G 4 / 20 p.R307fs c.919delC COSV68125708 Tier2 1 / 106
chr5:56160653 C CAAAGTGATGCG 4 / 20 p.A314fs c.928_938dupAAAGTGATGCG   Tier2 1 / 106
chr5:56161270 T G 5 / 20 p.L380* c.1139T>G   Tier2 1 / 106
chr5:56168547 C G 8 / 20 p.Y501* c.1503C>G   Tier2 1 / 106
chr5:56168663 CA C 9 / 20 p.S507fs c.1519delA   Tier2 1 / 106
chr5:56168740 C T 9 / 20 p.R532* c.1594C>T COSV68123693 Tier2 1 / 106
chr5:56176614 G T 12 / 20 p.E722* c.2164G>T COSV68128615 Tier2 1 / 106
chr5:56176943 T G 13 / 20 p.L738* c.2213T>G   Tier2 1 / 106
chr5:56176963 C T 13 / 20 p.Q745* c.2233C>T   Tier2 1 / 106
chr5:56177456 C A 14 / 20 p.S810* c.2429C>A   Tier2 1 / 106
chr5:56178036 GCATAGACT G 14 / 20 p.H1004fs c.3010_3017delCATAGACT   Tier2 1 / 106
chr5:56178063 C A 14 / 20 p.C1012* c.3036C>A   Tier2 1 / 106
chr5:56178143 CA C 14 / 20 p.D1040fs c.3117delA   Tier2 1 / 106
chr5:56178195 CAT C 14 / 20 p.I1057fs c.3170_3171delTA   Tier2 1 / 106
chr5:56178470 C CTT 14 / 20 p.K1150fs c.3446_3447dupTT   Tier2 1 / 106
chr5:56179492 ATGGC A 15 / 20 p.A1270fs c.3808_3811delGCTG   Tier2 1 / 106
chr5:56180553 GAT G 16 / 20 p.I1295fs c.3884_3885delTA COSV68123228 Tier2 1 / 106
chr5:56181789 A ATGGAGCCT 17 / 20 p.F1341fs c.4015_4022dupGGAGCCTT   Tier2 1 / 106
chr5:56181803 G T 17 / 20 p.E1343* c.4027G>T COSV68127321 Tier2 2 / 106
chr5:56181834 T A 17 / 20 p.L1353* c.4058T>A   Tier2 1 / 106
chr5:56183234 C T 18 / 20 p.Q1382* c.4144C>T COSV68126240 Tier2 1 / 106
chr5:56189442 C T 20 / 20 p.Q1492* c.4474C>T COSV68127064 Tier2 1 / 106