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Basic information

Official gene symbol
menin 1
Conventional gene symbol
MEAI, SCG2
Classification
Tumor suppressor gene
Official gene ID
4221(Refseq)
4221 (KEGG)
Transcript ID
NM_130803
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
11q13.1 (chr11:64571806..64577581, complement)
Protein length
615

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr11:64577320 CGGCGATGATAGACAGGTCGGCCACGGGAAAGTAGGTGAGGCCGCCA C 2 / 10 p.G73fs c.216_261delTGGCGGCCTCACCTACTTTCCCGTGGCCGACCTGTCTATCATCGCC   Tier2 1 / 55
chr11:64577332 AC A 2 / 10 p.S84fs c.249delG   Tier2 1 / 55
chr11:64577392 G A 2 / 10 p.Q64* c.190C>T COSV56343373 Tier2 1 / 55
chr11:64577506 C A 2 / 10 p.E26* c.76G>T   Tier2 1 / 55
chr11:64575424 C T 3 / 10 p.W203* c.608G>A COSV53641292 Tier2 1 / 55
chr11:64573799 GATGTGTTCATCCCGAT G 7 / 10 p.Y318fs c.953_968delATCGGGATGAACACAT   Tier2 1 / 55
chr11:64572549 C T 9 / 10 p.W441* c.1322G>A   Tier2 1 / 55
chr11:64571907 G A 10 / 10 p.Q583* c.1747C>T   Tier2 1 / 55
chr11:64571928 TG T 10 / 10 p.N576fs c.1725delC   Tier2 1 / 55
chr11:64572060 G A 10 / 10 p.R532* c.1594C>T COSV53646258 Tier2 1 / 55