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MRE11
Basic information
- Official gene symbol
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MRE11 homolog, double strand break repair nuclease
- Conventional gene symbol
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ATLD, HNGS1, MRE11A, MRE11B
- Classification
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- Official gene ID
- Transcript ID
- Functional classification
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Genome maintenance
- Signaling pathway
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Core DNA Damage Response
- Chromosomal location
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11q21 (chr11:94153291..94225967, complement)
- Protein length
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708
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr11:94200981 | G | A | 10 / 20 | p.R366* | c.1096C>T | COSV60578898 | Tier2 | 1 / 62 |
| chr11:94200987 | G | A | 10 / 20 | p.R364* | c.1090C>T | COSV60577289(SNP) | Tier2 | 1 / 62 |
| chr11:94194200 | C | A | 12 / 20 | p.E410* | c.1228G>T | Tier2 | 1 / 62 | |
| chr11:94189462 | C | A | 14 / 20 | p.E515* | c.1543G>T | Tier2 | 1 / 62 |