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MSH3
Basic information
- Official gene symbol
-
mutS homolog 3
- Conventional gene symbol
-
DUP, FAP4
- Classification
-
Tumor suppressor gene
- Official gene ID
- Transcript ID
- Functional classification
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Genome maintenance
- Signaling pathway
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Core DNA Damage Response
- Chromosomal location
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5q14.1 (chr5:79950547..80171681)
- Protein length
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1,137
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr5:79950741 | G | GCCCCCCAGCGC | 1 / 24 | p.A68fs | c.200_201insCAGCGCCCCCC | Tier2 | 1 / 74 | |
| chr5:80057476 | CTG | C | 13 / 24 | p.C626fs | c.1877_1878delGT | Tier2 | 1 / 74 | |
| chr5:80064769 | C | T | 15 / 24 | p.R734* | c.2200C>T | Tier2 | 1 / 74 |