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MTOR

Basic information

Official gene symbol
mechanistic target of rapamycin kinase
Conventional gene symbol
FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
Classification
Oncogene
Official gene ID
2475(Refseq)
2475 (KEGG)
Transcript ID
NM_004958
Functional classification
Tumor growth and progression
Signaling pathway
PI3K/Akt/mTOR
Chromosomal location
1p36.22 (chr1:11167542..11319466, complement)
Protein length
2,549

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr1:11217299 A G 30 / 58 p.L1460P c.4379T>C COSV63868845 Tier1 1 / 176
chr1:11217303 C G 30 / 58 p.A1459P c.4375G>C COSV63869424 Tier2 1 / 176
chr1:11190804 C T 39 / 58 p.E1799K c.5395G>A COSV63869964 Tier2 8 / 176
chr1:11189845 G T 40 / 58 p.F1888L c.5664C>A COSV63869154 Tier2 1 / 176
chr1:11188078 C A 43 / 58 p.V2006F c.6016G>T COSV63868121 Tier2 1 / 176
chr1:11188164 G A 43 / 58 p.T1977I c.5930C>T COSV63868784 Tier1 1 / 176
chr1:11188164 G T 43 / 58 p.T1977K c.5930C>A COSV63869673 Tier1 2 / 176
chr1:11184573 G A 47 / 58 p.S2215F c.6644C>T COSV63868278 Tier1 4 / 176
chr1:11184573 G T 47 / 58 p.S2215Y c.6644C>A COSV63868313 Tier2 4 / 176
chr1:11182158 A C 48 / 58 p.L2230V c.6688T>G COSV63875963 Tier1 1 / 176
chr1:11174395 A C 53 / 58 p.L2427R c.7280T>G COSV63869220 Tier2 3 / 176
chr1:11174420 C T 53 / 58 p.E2419K c.7255G>A COSV63869451 Tier1 1 / 176
chr1:11169377 T A 56 / 58 p.I2500F c.7498A>T COSV63869574 Tier2 1 / 176