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NCOR1

Basic information

Official gene symbol
nuclear receptor corepressor 1
Conventional gene symbol
N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR
Classification
Tumor suppressor gene
Official gene ID
9611(Refseq)
9611 (KEGG)
Transcript ID
NM_006311
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
17p12-p11.2 (chr17:15935610..16097883, complement)
Protein length
2,440

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr17:16068381 G C 5 / 46 p.S177* c.530C>G COSV51982809 Tier2 1 / 134
chr17:16042434 G A 12 / 46 p.R414* c.1240C>T COSV51970466 Tier2 1 / 134
chr17:16024504 G A 16 / 46 p.R572* c.1714C>T COSV51982020 Tier2 2 / 134
chr17:16001704 G A 21 / 46 p.R933* c.2797C>T COSV51960299 Tier2 1 / 134
chr17:15995252 C A 22 / 46 p.E981* c.2941G>T   Tier2 1 / 134
chr17:15995309 G A 22 / 46 p.R962* c.2884C>T COSV51961400 Tier2 3 / 134
chr17:15989634 C A 23 / 46 p.E1047* c.3139G>T   Tier2 1 / 134
chr17:15978977 CCT C 27 / 46 p.E1180fs c.3539_3540delAG   Tier2 1 / 134
chr17:15978998 G A 27 / 46 p.Q1174* c.3520C>T   Tier2 1 / 134
chr17:15974966 T TGCTC 30 / 46 p.T1304fs c.3905_3908dupGAGC   Tier2 1 / 134
chr17:15973505 GAGCC G 31 / 46 p.G1495fs c.4483_4486delGGCT   Tier2 1 / 134
chr17:15973661 AC A 31 / 46 p.V1444fs c.4330delG   Tier2 1 / 134
chr17:15973811 G C 31 / 46 p.S1394* c.4181C>G COSV51962844 Tier2 1 / 134
chr17:15968799 C A 33 / 46 p.G1651* c.4951G>T   Tier2 1 / 134
chr17:15965070 ACT A 37 / 46 p.S1842fs c.5524_5525delAG   Tier2 1 / 134
chr17:15965154 G C 37 / 46 p.Y1814* c.5442C>G   Tier2 1 / 134
chr17:15960870 G C 40 / 46 p.S2117* c.6350C>G COSV99246870 Tier2 1 / 134
chr17:15960880 T A 40 / 46 p.R2114* c.6340A>T   Tier2 1 / 134
chr17:15952164 C CTT 41 / 46 p.Q2178fs c.6530_6531insAA   Tier2 1 / 134