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NOTCH2

Basic information

Official gene symbol
notch receptor 2
Conventional gene symbol
AGS2, HJCYS, hN2
Classification
Oncogene / Tumor suppressor gene
Official gene ID
4853(Refseq)
4853 (KEGG)
Transcript ID
NM_024408
Functional classification
Differentiation
Signaling pathway
NOTCH
Chromosomal location
1p12 (chr1:120457929..120612020, complement)
Protein length
2,471

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr1:120512340 TC T 6 / 34 p.E301fs c.901delG   Tier2 1 / 146
chr1:120510096 A T 8 / 34 p.C471* c.1413T>A   Tier2 1 / 146
chr1:120484198 C A 18 / 34 p.G978* c.2932G>T   Tier2 1 / 146
chr1:120483236 TC T 19 / 34 p.D1042fs c.3124delG   Tier2 1 / 146
chr1:120462965 C T 30 / 34 p.W1789* c.5366G>A COSV99867224 Tier2 1 / 146
chr1:120462204 G A 31 / 34 p.R1838* c.5512C>T COSV56688328 Tier2 1 / 146
chr1:120458200 TTGCCCACAGAGGCTGG T 34 / 34 p.P2377fs c.7129_7144delCCAGCCTCTGTGGGCA   Tier2 1 / 146