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NRAS

Basic information

Official gene symbol
NRAS proto-oncogene, GTPase
Conventional gene symbol
ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6
Classification
Oncogene
Official gene ID
4893(Refseq)
4893 (KEGG)
Transcript ID
NM_002524
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
1p13.2 (chr1:115251156..115258781, complement)
Protein length
189

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr1:115258744 C T 2 / 7 p.G13D c.38G>A COSV54736416 Tier1 3 / 66
chr1:115258745 C A 2 / 7 p.G13C c.37G>T COSV54736386 Tier1 1 / 66
chr1:115258745 C G 2 / 7 p.G13R c.37G>C COSV54736550 Tier1 4 / 66
chr1:115258747 C T 2 / 7 p.G12D c.35G>A COSV54736383 Tier1 14 / 66
chr1:115258747 C A 2 / 7 p.G12V c.35G>T COSV54736974 Tier1 2 / 66
chr1:115258748 C T 2 / 7 p.G12S c.34G>A COSV54736621 Tier1 5 / 66
chr1:115258748 C A 2 / 7 p.G12C c.34G>T COSV54736487 Tier1 2 / 66
chr1:115258748 C G 2 / 7 p.G12R c.34G>C COSV54736940 Tier1 1 / 66
chr1:115256528 T G 3 / 7 p.Q61H c.183A>C COSV54736320 Tier1 2 / 66
chr1:115256529 T A 3 / 7 p.Q61L c.182A>T COSV54736624 Tier1 5 / 66
chr1:115256529 T C 3 / 7 p.Q61R c.182A>G COSV54736340 Tier1 4 / 66
chr1:115256530 G T 3 / 7 p.Q61K c.181C>A COSV54736310 Tier1 7 / 66