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PARP1

Basic information

Official gene symbol
poly(ADP-ribose) polymerase 1
Conventional gene symbol
ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Classification
Tumor suppressor gene
Official gene ID
142(Refseq)
142 (KEGG)
Transcript ID
NM_001618
Functional classification
Genome maintenance
Signaling pathway
Core DNA Damage Response
Chromosomal location
1q42.12 (chr1:226549161..226595630, complement)
Protein length
1,014

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr1:226578127 C A 4 / 23 p.G201* c.601G>T COSV64688382 Tier2 1 / 59
chr1:226567857 C A 10 / 23 p.E437* c.1309G>T   Tier2 1 / 59