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PDGFRA

Basic information

Official gene symbol
platelet derived growth factor receptor alpha
Conventional gene symbol
CD140A, PDGFR-2, PDGFR2
Classification
Oncogene
Official gene ID
5156(Refseq)
5156 (KEGG)
Transcript ID
NM_006206
Functional classification
Tumor growth and progression
Signaling pathway
RTK
Chromosomal location
4q12 (chr4:55124936..55161439)
Protein length
1,089

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr4:55140746 T A 11 / 23 p.V536E c.1607T>A COSV57271679 Tier1 1 / 112
chr4:55141036 T A 12 / 23 p.V561D c.1682T>A COSV57265452 Tier1 1 / 112
chr4:55152091 AGACATCATG A 18 / 23 p.D842_M844del c.2524_2532delGACATCATG COSV57266334 Tier2 1 / 112
chr4:55152092 G T 18 / 23 p.D842Y c.2524G>T COSV57269122 Tier2 1 / 112
chr4:55152093 A T 18 / 23 p.D842V c.2525A>T COSV57264120 Tier1 3 / 112
chr4:55152126 G A 18 / 23 p.G853D c.2558G>A   Tier1 1 / 112