PIK3CA

Basic information

Official gene symbol: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Conventional gene symbol: CLAPO, CLOVE, CWS5, MCM, MCMTC, PI3K-alpha, p110-alpha
Classification: Oncogene
Official gene ID: 5290(Refseq)

5290 (KEGG)
Transcript ID: NM_006218

Functional classification: Tumor growth and progression
Signaling pathway: PI3K/Akt/mTOR
Chromosomal location: 3q26.32 (chr3:178916614..178952152)
Protein length: 1,068

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19)	Reference	Variant	Exon	Amino Acid change	Coding DNA change	COSMIC (v92)	Classification	No. of Samples
chr3:178916726	G	A	2 / 21	p.R38H	c.113G>A	COSV55879949	Tier1	1 / 560
chr3:178916854	G	A	2 / 21	p.E81K	c.241G>A	COSV55873676	Tier2	6 / 560
chr3:178916876	G	A	2 / 21	p.R88Q	c.263G>A	COSV55874568	Tier2	33 / 560
chr3:178916890	C	T	2 / 21	p.R93W	c.277C>T	COSV55874903	Tier2	7 / 560
chr3:178916891	G	A	2 / 21	p.R93Q	c.278G>A	COSV55877982	Tier2	3 / 560
chr3:178916929	G	C	2 / 21	p.G106R	c.316G>C	COSV55878215	Tier2	1 / 560
chr3:178916930	G	T	2 / 21	p.G106V	c.317G>T	COSV55874291	Tier2	2 / 560
chr3:178916930	G	A	2 / 21	p.G106D	c.317G>A	COSV55926774	Tier2	1 / 560
chr3:178916936	G	A	2 / 21	p.R108H	c.323G>A	COSV55873442	Tier2	12 / 560
chr3:178916937	TGAA	T	2 / 21	p.E110del	c.328_330delGAA	COSV55874554	Tier2	1 / 560
chr3:178916944	A	G	2 / 21	p.K111E	c.331A>G	COSV55878486	Tier1	3 / 560
chr3:178916946	G	T	2 / 21	p.K111N	c.333G>T	COSV55876538	Tier2	3 / 560
chr3:178917478	G	A	3 / 21	p.G118D	c.353G>A	COSV55877290	Tier2	8 / 560
chr3:178921548	G	A	5 / 21	p.V344M	c.1030G>A	COSV55881590	Tier2	3 / 560
chr3:178921549	T	G	5 / 21	p.V344G	c.1031T>G	COSV55876054	Tier2	1 / 560
chr3:178921551	A	C	5 / 21	p.N345H	c.1033A>C	COSV55957136	Tier2	1 / 560
chr3:178921552	A	C	5 / 21	p.N345T	c.1034A>C	COSV55902438	Tier2	2 / 560
chr3:178921552	A	T	5 / 21	p.N345I	c.1034A>T	COSV55902706	Tier2	1 / 560
chr3:178921553	T	A	5 / 21	p.N345K	c.1035T>A	COSV55873276	Tier1	10 / 560
chr3:178922321	G	A	6 / 21	p.G364R	c.1090G>A	COSV55903618	Tier2	1 / 560
chr3:178922324	G	A	6 / 21	p.E365K	c.1093G>A	COSV55881636	Tier2	1 / 560
chr3:178922363	T	C	6 / 21	p.C378R	c.1132T>C	COSV55882697	Tier2	1 / 560
chr3:178927980	T	C	8 / 21	p.C420R	c.1258T>C	COSV55874020	Tier1	17 / 560
chr3:178928067	C	A	8 / 21	p.P449T	c.1345C>A	COSV55932192	Tier1	1 / 560
chr3:178928079	G	A	8 / 21	p.E453K	c.1357G>A	COSV55874585	Tier1	8 / 560
chr3:178928079	G	C	8 / 21	p.E453Q	c.1357G>C	COSV55873816	Tier2	1 / 560
chr3:178936082	G	A	10 / 21	p.E542K	c.1624G>A	COSV55873227	Tier1	66 / 560
chr3:178936082	G	C	10 / 21	p.E542Q	c.1624G>C	COSV55894248	Tier2	4 / 560
chr3:178936083	A	T	10 / 21	p.E542V	c.1625A>T	COSV55881194	Tier1	2 / 560
chr3:178936083	A	C	10 / 21	p.E542A	c.1625A>C	COSV55893680	Tier2	2 / 560
chr3:178936091	G	A	10 / 21	p.E545K	c.1633G>A	COSV55873239	Tier1	88 / 560
chr3:178936091	G	C	10 / 21	p.E545Q	c.1633G>C	COSV55878227	Tier1	1 / 560
chr3:178936092	A	C	10 / 21	p.E545A	c.1634A>C	COSV55873209	Tier1	8 / 560
chr3:178936092	A	G	10 / 21	p.E545G	c.1634A>G	COSV55873220	Tier1	8 / 560
chr3:178936093	G	C	10 / 21	p.E545D	c.1635G>C	COSV55875881	Tier2	2 / 560
chr3:178936094	C	A	10 / 21	p.Q546K	c.1636C>A	COSV55873527	Tier1	13 / 560
chr3:178936094	C	G	10 / 21	p.Q546E	c.1636C>G	COSV55882350	Tier1	2 / 560
chr3:178936095	A	G	10 / 21	p.Q546R	c.1637A>G	COSV55876869	Tier1	7 / 560
chr3:178936095	A	C	10 / 21	p.Q546P	c.1637A>C	COSV55875400	Tier1	2 / 560
chr3:178936096	G	T	10 / 21	p.Q546H	c.1638G>T	COSV55883555	Tier2	1 / 560
chr3:178938934	G	A	14 / 21	p.E726K	c.2176G>A	COSV55875460	Tier2	6 / 560
chr3:178947865	G	C	19 / 21	p.G914R	c.2740G>C	COSV55944375	Tier2	1 / 560
chr3:178948136	G	A	20 / 21	p.E970K	c.2908G>A	COSV55875690	Tier2	2 / 560
chr3:178952007	A	G	21 / 21	p.Y1021C	c.3062A>G	COSV55882161	Tier2	5 / 560
chr3:178952018	A	G	21 / 21	p.T1025A	c.3073A>G	COSV55873252	Tier1	5 / 560
chr3:178952072	A	G	21 / 21	p.M1043V	c.3127A>G	COSV55879858	Tier1	3 / 560
chr3:178952073	T	C	21 / 21	p.M1043T	c.3128T>C	COSV55900332	Tier2	1 / 560
chr3:178952074	G	A	21 / 21	p.M1043I	c.3129G>A	COSV55873376	Tier1	1 / 560
chr3:178952074	G	C	21 / 21	p.M1043I	c.3129G>C	COSV55898229	Tier1	1 / 560
chr3:178952074	G	T	21 / 21	p.M1043I	c.3129G>T	COSV55878974	Tier1	4 / 560
chr3:178952077	T	A	21 / 21	p.N1044K	c.3132T>A	COSV55897116	Tier1	1 / 560
chr3:178952077	T	G	21 / 21	p.N1044K	c.3132T>G	COSV55875087	Tier1	1 / 560
chr3:178952084	C	T	21 / 21	p.H1047Y	c.3139C>T	COSV55876499	Tier1	4 / 560
chr3:178952085	A	G	21 / 21	p.H1047R	c.3140A>G	COSV55873195	Tier1	120 / 560
chr3:178952085	A	T	21 / 21	p.H1047L	c.3140A>T	COSV55873401	Tier1	21 / 560
chr3:178952090	G	C	21 / 21	p.G1049R	c.3145G>C	COSV55874453	Tier1	7 / 560
chr3:178952090	G	A	21 / 21	p.G1049S	c.3145G>A	COSV55878564	Tier2	2 / 560
chr3:178952142	C	T	21 / 21	p.A1066V	c.3197C>T	COSV55892714	Tier2	1 / 560