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PIK3CB

Basic information

Official gene symbol
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Conventional gene symbol
P110BETA, PI3KBETA, PIK3C1
Classification
Oncogene
Official gene ID
5291(Refseq)
5291 (KEGG)
Transcript ID
NM_006219
Functional classification
Tumor growth and progression
Signaling pathway
PI3K/Akt/mTOR
Chromosomal location
3q22.3 (chr3:138374231..138478185, complement)
Protein length
1,070

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr3:138426123 C T 9 / 24 p.E470K c.1408G>A COSV56683158 Tier1 1 / 61
chr3:138374244 T A 22 / 24 p.D1067V c.3200A>T COSV56683107 Tier1 2 / 61
chr3:138374245 C A 22 / 24 p.D1067Y c.3199G>T COSV56684065 Tier1 1 / 61
chr3:138374293 C T 22 / 24 p.E1051K c.3151G>A COSV56683948 Tier2 2 / 61