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PIK3R1

Basic information

Official gene symbol
phosphoinositide-3-kinase regulatory subunit 1
Conventional gene symbol
AGM7, GRB1, IMD36, p85-ALPHA
Classification
Tumor suppressor gene
Official gene ID
5295(Refseq)
5295 (KEGG)
Transcript ID
NM_181523
Functional classification
Tumor growth and progression
Signaling pathway
PI3K/Akt/mTOR
Chromosomal location
5q13.1 (chr5:67522504..67593429)
Protein length
724

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr5:67522602 TAA T 2 / 16 p.K34fs c.101_102delAA   Tier2 1 / 135
chr5:67522657 G T 2 / 16 p.E52* c.154G>T COSV57124346 Tier2 1 / 135
chr5:67522726 G T 2 / 16 p.E75* c.223G>T   Tier2 2 / 135
chr5:67522748 TCTCGC T 2 / 16 p.P84fs c.249_253delGCCTC   Tier2 1 / 135
chr5:67569823 C T 4 / 16 p.R162* c.484C>T COSV57127263 Tier2 1 / 135
chr5:67576373 G T 6 / 16 p.E218* c.652G>T COSV57137973 Tier2 1 / 135
chr5:67588153 TA T 8 / 16 p.L328fs c.984delA   Tier2 1 / 135
chr5:67588951 C T 9 / 16 p.R348* c.1042C>T COSV57123475 Tier1 4 / 135
chr5:67589138 G C 10 / 16 p.G376R c.1126G>C COSV57133701 Tier2 1 / 135
chr5:67589138 G A 10 / 16 p.G376R c.1126G>A COSV57123316 Tier2 1 / 135
chr5:67589147 A G 10 / 16 p.K379E c.1135A>G COSV57124239 Tier1 1 / 135
chr5:67589168 C T 10 / 16 p.R386* c.1156C>T COSV57126203 Tier2 5 / 135
chr5:67589549 AAAG A 11 / 16 p.E439del c.1317_1319delAGA COSV57133720 Tier2 1 / 135
chr5:67589593 T A 11 / 16 p.Y452* c.1356T>A   Tier2 1 / 135
chr5:67589606 C T 11 / 16 p.Q457* c.1369C>T   Tier2 1 / 135
chr5:67589618 C T 11 / 16 p.R461* c.1381C>T COSV57125001 Tier2 2 / 135
chr5:67590432 C A 12 / 16 p.C498* c.1494C>A COSV57139021 Tier2 1 / 135
chr5:67591007 C T 13 / 16 p.R534* c.1600C>T COSV57137455 Tier2 1 / 135
chr5:67591076 C T 13 / 16 p.R557* c.1669C>T COSV57125577 Tier2 2 / 135
chr5:67591085 G T 13 / 16 p.D560Y c.1678G>T COSV57123942 Tier2 1 / 135
chr5:67591097 A G 13 / 16 p.N564D c.1690A>G COSV57124003 Tier1 4 / 135
chr5:67591113 A ACCTT 13 / 16 p.I571fs c.1707_1710dupCCTT   Tier2 1 / 135
chr5:67591131 AGAC A 13 / 16 p.T576del c.1727_1729delCGA COSV57124497 Tier1 1 / 135
chr5:67591135 GAGAGACCAATACTTGATGT G 13 / 16 p.R577fs c.1730_1745+3delGAGACCAATACTTGATGTA COSV57137283 Tier2 1 / 135
chr5:67591312 G T 14 / 16 p.E604* c.1810G>T   Tier2 2 / 135
chr5:67592075 C T 15 / 16 p.R631* c.1891C>T COSV57134805 Tier2 1 / 135
chr5:67592108 C T 15 / 16 p.R642* c.1924C>T COSV57123056 Tier2 2 / 135
chr5:67592163 C CTG 15 / 16 p.V662fs c.1981_1982dupGT COSV99140531 Tier2 2 / 135
chr5:67592165 G GT 15 / 16 p.V662fs c.1982dupT   Tier2 1 / 135
chr5:67593269 TAAAC T 16 / 16 p.N673fs c.2019_2022delCAAA COSV99073799 Tier2 1 / 135
chr5:67593331 G T 16 / 16 p.E693* c.2077G>T   Tier2 1 / 135